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PF3D7_1467300 1-deoxy-D-xylulose 5-phosphate reductoisomerase [ Plasmodium falciparum 3D7 ]

Gene ID: 812223, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_1467300
Gene description
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Locus tag
PF3D7_1467300
Gene type
protein coding
RNA name
1-deoxy-D-xylulose 5-phosphate reductoisomerase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 14
Exon count:
1
Sequence:
Chromosome: 14; NC_037283.1 (2750958..2752424)

Chromosome 14 - NC_037283.1Genomic Context describing neighboring genes Neighboring gene DNA-3-methyladenine glycosylase, putative Neighboring gene WD repeat-containing protein 79, putative Neighboring gene 50S ribosomal protein L22, apicoplast, putative Neighboring gene DNA/RNA-binding protein KIN17, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037283.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In silico identification of promiscuous scaffolds as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria. Wadood A, et al. Pharm Biol, 2017 Dec. PMID 27650666, Free PMC Article
  2. Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum. Umeda T, et al. Sci Rep, 2011. PMID 22355528, Free PMC Article
  3. Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways. Baumeister S, et al. PLoS One, 2011 May 4. PMID 21573242, Free PMC Article
  4. The malarial drug target Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR): development of a 3-D model for identification of novel, structural and functional features and for inhibitor screening. Goble JL, et al. Protein Pept Lett, 2010 Jan. PMID 20214634
  5. Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene. Odom AR, et al. Mol Biochem Parasitol, 2010 Apr. PMID 20018214, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Innovative scaffolds with novel modes of action, improved efficacy and acceptable physiochemical/pharmacokinetic properties were computationally identified as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria.
    Title: In silico identification of promiscuous scaffolds as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria.
  2. Data indicate that IspC (1-deoxy-D-xylulose 5-phosphate reductoisomerase) displays a high level of enantioselectivity for an alpha-substituted fosmidomycin derivative.
    Title: IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters.
  3. A three-dimensional model of the malarial drug target protein PfDXR was generated, and validated using structure-checking programs and protein docking studies.
    Title: The malarial drug target Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR): development of a 3-D model for identification of novel, structural and functional features and for inhibitor screening.
  4. These data indicate that deoxyxylulose 5-phosphate reductoisomerase is required for intraerythrocytic development of Plasmodium falciparum.
    Title: Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by GeneDB

Process Evidence Code Pubs
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apicoplast HDA PubMed 
located_in apicoplast IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Names
MEP synthase
XP_001348815.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_037283.1 Reference assembly

    Range
    2750958..2752424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001348779.1 → XP_001348815.1  1-deoxy-D-xylulose 5-phosphate reductoisomerase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001348815.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A144A2T4, O96693, Q8IKG4
    UniProtKB/TrEMBL
    A0A024UY83, A0A024VJS7, A0A024WHA3, A0A024X1G0, A0A0L1I9Z9, W4I8U8, W4IWG8, W7F391, W7FQT1, W7JFS8, W7JLE6
    Conserved Domains (1) summary
    PRK05447
    Location:79 → 485
    PRK05447; 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IKG4.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases