Ntng1 netrin G1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ntng1provided by MGI
Official Full Name: netrin G1provided by MGI
Primary source: MGI:MGI:1934028
See related: Ensembl:ENSMUSG00000059857 AllianceGenome:MGI:1934028
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lmnt1; A930010C08Rik
Summary: Predicted to enable cell-cell adhesion mediator activity. Involved in several processes, including regulation of cell projection organization; regulation of neuron migration; and synaptic membrane adhesion. Acts upstream of or within axonogenesis. Located in Schaffer collateral - CA1 synapse and plasma membrane. Is anchored component of presynaptic active zone membrane. Is active in glutamatergic synapse. Is expressed in brain and enteric nervous system. Orthologous to human NTNG1 (netrin G1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 3.3), whole brain E14.5 (RPKM 3.0) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F3; 3 48.47 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (109687366..110057291, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (109780050..110149972, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A role for axon-glial interactions and Netrin-G1 signaling in the formation of low-threshold mechanoreceptor end organs.
Title: A role for axon-glial interactions and Netrin-G1 signaling in the formation of low-threshold mechanoreceptor end organs.
Decreased Ntng1 expression was initially observed in the nucleus accumbens of mice conditioned to cocaine.
Title: Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human cocaine dependence.
findings support a crucial role for netrin-G1 in dissociable neural circuits for the modulation of emotion-related behaviors, and provide genetic models for investigating the mechanisms underlying the dissociation.
Title: Netrin-G1 regulates fear-like and anxiety-like behaviors in dissociable neural circuits.
Pre-synaptic netrin-G1 and netrin-G2 diversify the complexity of vertebrate behaviors and differentially regulate post-synaptic properties.
Title: Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins.
netrin-G/NGL interactions differentially control synaptic plasticity in distinct circuits via retrograde signaling mechanisms
Title: Netrin-G/NGL complexes encode functional synaptic diversification.
The complementary expression patterns of Ntng1 and Ntng2 are determined by transcriptional cis-regulatory elements widely scattered in these loci.
Title: Identification of transcriptional regulatory elements for Ntng1 and Ntng2 genes in mice.
selectively expressed in distinct neuronal subsets that include populations in forebrain, midbrain, hindbrain, spinal cord, and spinal ganglia
Title: Laminets: laminin- and netrin-related genes expressed in distinct neuronal subsets.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

12_5_5_1.seq (e-PCR)
- UniSTS:123146

12_5_5_6.seq (e-PCR)
- UniSTS:123147

NoName (e-PCR)
- UniSTS:234806

Ntng1 (e-PCR), detects polymorphism
- UniSTS:526910

AI853992 (e-PCR)
- UniSTS:165289

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables cell-cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron projection arborization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: netrin-G1

Names: laminet-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163348.1 → NP_001156820.1 netrin-G1 isoform b

See identical proteins and their annotated locations for NP_001156820.1

Status: VALIDATED

Description

Transcript Variant: This variant (b) lacks an alternate in-frame exon compared to variant a. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AB038666, AB038667, AK034465, BB621591, BC079881

Consensus CDS

CCDS59652.1

UniProtKB/TrEMBL

F8WJ51

Related

ENSMUSP00000120688.3, ENSMUST00000138344.9

Conserved Domains (3) summary

smart00180
Location:364 → 411

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:296 → 342

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00055
Location:71 → 295

Laminin_N; Laminin N-terminal (Domain VI)
NM_001163349.1 → NP_001156821.1 netrin-G1 isoform c

See identical proteins and their annotated locations for NP_001156821.1

Status: VALIDATED

Description

Transcript Variant: This variant (c) lacks two alternate in-frame exons compared to variant a. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AB038665, AB038667, AK034465, BB621591, BC079881

Consensus CDS

CCDS59651.1

UniProtKB/TrEMBL

F8WJ51

Related

ENSMUSP00000117371.3, ENSMUST00000133268.9

Conserved Domains (3) summary

cd00054
Location:373 → 397

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:296 → 342

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00055
Location:71 → 295

Laminin_N; Laminin N-terminal (Domain VI)
NM_001163350.1 → NP_001156822.1 netrin-G1 isoform d

See identical proteins and their annotated locations for NP_001156822.1

Status: VALIDATED

Description

Transcript Variant: This variant (d) lacks two alternate in-frame exons and contains two other alternate in-frame exons compared to variant a. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AB038664, AB038667, AK034465, BB621591, BC079881

Consensus CDS

CCDS59654.1

UniProtKB/TrEMBL

F8WJ50

Related

ENSMUSP00000116213.3, ENSMUST00000138953.9

Conserved Domains (3) summary

cd00054
Location:415 → 439

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:296 → 342

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00055
Location:71 → 295

Laminin_N; Laminin N-terminal (Domain VI)
NM_030699.2 → NP_109624.1 netrin-G1 isoform a precursor

See identical proteins and their annotated locations for NP_109624.1

Status: VALIDATED

Description

Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AB038667, AK034465, BB621591

Consensus CDS

CCDS38604.1

UniProtKB/Swiss-Prot

Q68FE5, Q69ZU3, Q8R4F3, Q8R4F4, Q8R4F5, Q8R4F6, Q8R4F7, Q8R4F8, Q8R4F9, Q8R4G0, Q9ESR3, Q9ESR4, Q9ESR5, Q9ESR6, Q9ESR7, Q9ESR8

UniProtKB/TrEMBL

F8WJ48

Related

ENSMUSP00000072397.6, ENSMUST00000072596.12

Conserved Domains (3) summary

smart00180
Location:420 → 467

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:296 → 342

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00055
Location:71 → 295

Laminin_N; Laminin N-terminal (Domain VI)
NM_133488.1 → NP_597995.1 netrin-G1 isoform e precursor

See identical proteins and their annotated locations for NP_597995.1

Status: VALIDATED

Description

Transcript Variant: This variant (e) lacks two alternate in-frame exons and contains another alternate in-frame exon compared to variant a. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AB038663, AB038667, AK034465, BB621591, BC079881

Consensus CDS

CCDS59653.1

UniProtKB/TrEMBL

F8WJ51

Related

ENSMUSP00000119534.3, ENSMUST00000156177.9

Conserved Domains (3) summary

cd00054
Location:395 → 419

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:296 → 342

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00055
Location:71 → 295

Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

109687366..110057291 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240295.4 → XP_011238597.1 netrin-G1 isoform X5

UniProtKB/TrEMBL

F8WJ48

Related

ENSMUSP00000118800.3, ENSMUST00000131027.9

Conserved Domains (2) summary

cd00055
Location:296 → 342

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00055
Location:71 → 295

Laminin_N; Laminin N-terminal (Domain VI)
XM_011240294.4 → XP_011238596.1 netrin-G1 isoform X4

UniProtKB/TrEMBL

F8WJ51

Conserved Domains (3) summary

smart00180
Location:386 → 433

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:296 → 342

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00055
Location:71 → 295

Laminin_N; Laminin N-terminal (Domain VI)
XM_011240293.4 → XP_011238595.1 netrin-G1 isoform X3

UniProtKB/TrEMBL

F8WJ50

Conserved Domains (3) summary

smart00180
Location:406 → 453

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:296 → 342

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00055
Location:71 → 295

Laminin_N; Laminin N-terminal (Domain VI)
XM_011240292.4 → XP_011238594.1 netrin-G1 isoform X2

UniProtKB/TrEMBL

F8WJ50

Conserved Domains (3) summary

cd00054
Location:471 → 495

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:296 → 342

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00055
Location:71 → 295

Laminin_N; Laminin N-terminal (Domain VI)
XM_011240291.4 → XP_011238593.1 netrin-G1 isoform X1

See identical proteins and their annotated locations for XP_011238593.1

UniProtKB/TrEMBL

F8WJ48

Conserved Domains (3) summary

smart00180
Location:462 → 509

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:296 → 342

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00055
Location:71 → 295

Laminin_N; Laminin N-terminal (Domain VI)
XM_006502355.5 → XP_006502418.1 netrin-G1 isoform X1

See identical proteins and their annotated locations for XP_006502418.1

UniProtKB/TrEMBL

F8WJ48

Conserved Domains (3) summary

smart00180
Location:462 → 509

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:296 → 342

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00055
Location:71 → 295

Laminin_N; Laminin N-terminal (Domain VI)

RNA

XR_001783784.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001163351.1: Suppressed sequence

Description

NM_001163351.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.