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Gpr12 G protein-coupled receptor 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 80840, updated on 13-Apr-2024

Summary

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Official Symbol
Gpr12provided by RGD
Official Full Name
G protein-coupled receptor 12provided by RGD
Primary source
RGD:68333
See related
Ensembl:ENSRNOG00000039832 AllianceGenome:RGD:68333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpcr12
Summary
Predicted to enable G protein-coupled receptor activity and phosphatidylcholine binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cellular calcium ion homeostasis. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human GPR12 (G protein-coupled receptor 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 22.1), Thymus (RPKM 6.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
12p11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (13636549..13640083)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (8522709..8525875)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (10253710..10257135)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095887 Neighboring gene uncharacterized LOC134481154 Neighboring gene uncharacterized LOC120095888 Neighboring gene uncharacterized LOC120095929

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Involvement of GPR12 in the induction of neurite outgrowth in PC12 cells. Lu X, et al. Brain Res Bull, 2012 Jan 4. PMID 21985983
  2. Cloning, sequencing and tissue distribution of a candidate G protein-coupled receptor from rat pituitary gland. Eidne KA, et al. FEBS Lett, 1991 Nov 4. PMID 1840531
  3. Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. Ignatov A, et al. J Neurosci, 2003 Feb 1. PMID 12574419, Free PMC Article
  4. The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes. Hinckley M, et al. Dev Biol, 2005 Nov 15. PMID 16229830
  5. Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. Song ZH, et al. Genomics, 1995 Jul 20. PMID 8530049

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings indicate that GPR12 may play a role in neurite outgrowth during PC12 cell differentiation.
    Title: Involvement of GPR12 in the induction of neurite outgrowth in PC12 cells.
  2. the cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12
    Title: The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC156481

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 12
Names
R334

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037295.2 → NP_001032372.1  G-protein coupled receptor 12

    See identical proteins and their annotated locations for NP_001032372.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    A0JPJ1, P30951
    UniProtKB/TrEMBL
    A6K1C8
    Related
    ENSRNOP00000057844.3, ENSRNOT00000061129.5
    Conserved Domains (1) summary
    cd15961
    Location:45 → 312
    7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_030831.2 → NP_110458.1  G-protein coupled receptor 12

    See identical proteins and their annotated locations for NP_110458.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    A0JPJ1, P30951
    UniProtKB/TrEMBL
    A6K1C8
    Conserved Domains (1) summary
    cd15961
    Location:45 → 312
    7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    13636549..13640083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598463.3 → XP_017453952.1  G-protein coupled receptor 12 isoform X1

  2. XM_039089797.2 → XP_038945725.1  G-protein coupled receptor 12 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:35 → 64
    7tm_GPCRs; TM helix 5 [structural motif]
    cl28897
    Location:1 → 153
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30951.3 GenPept UniProtKB/Swiss-Prot:P30951

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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