ptgesl prostaglandin E synthase 2-like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptgeslprovided by ZNC
Official Full Name: prostaglandin E synthase 2-likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1063
See related: Ensembl:ENSDARG00000068415 AllianceGenome:ZFIN:ZDB-GENE-040426-1063
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ptges2; zgc:56527
Summary: Predicted to enable several functions, including glutathione binding activity; heme binding activity; and prostaglandin-E synthase activity. Predicted to be involved in prostaglandin biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process and prostaglandin metabolic process. Predicted to be located in Golgi membrane. Predicted to be active in mitochondrion. Is expressed in female organism; male organism; and reproductive system. Orthologous to human PTGES2 (prostaglandin E synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (30998290..31013664)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (30999055..31004432)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 12-hydroxyheptadecatrienoic acid synthase activity	IEA Inferred from Electronic Annotation more info
enables glutathione binding	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	ISS Inferred from Sequence or Structural Similarity more info
enables prostaglandin-E synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-E synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prostaglandin E synthase 2

Names: mPGES-2; microsomal prostaglandin E synthase 2

NP_956574.1

EC 5.3.99.3

XP_021334006.1

EC 5.3.99.3

XP_021334007.1

EC 5.3.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200280.1 → NP_956574.1 prostaglandin E synthase 2

See identical proteins and their annotated locations for NP_956574.1

Status: PROVISIONAL

Source sequence(s)

BC049325

UniProtKB/Swiss-Prot

Q7ZUC7

Related

ENSDARP00000111602.2, ENSDART00000129882.3

Conserved Domains (3) summary

cd03197
Location:227 → 374

GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2

COG0625
Location:107 → 369

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03040
Location:106 → 179

GST_N_mPGES2; GST_N family; microsomal Prostaglandin E synthase Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored dimeric protein containing a CXXC motif which catalyzes the isomerization of PGH2 to PGE2. Unlike cytosolic PGE synthase (cPGES) and microsomal ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

30998290..31013664

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021478331.1 → XP_021334006.1 prostaglandin E synthase 2 isoform X1

UniProtKB/TrEMBL

A0A8M9QDX0

Conserved Domains (2) summary

cd03197
Location:87 → 234

GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2

cl00388
Location:1 → 39

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
XM_021478332.1 → XP_021334007.1 prostaglandin E synthase 2 isoform X2

UniProtKB/TrEMBL

A0A8M9PR36

Related

ENSDARP00000148650.1, ENSDART00000180694.1

Conserved Domains (1) summary

cd03040
Location:107 → 180

GST_N_mPGES2; GST_N family; microsomal Prostaglandin E synthase Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored dimeric protein containing a CXXC motif which catalyzes the isomerization of PGH2 to PGE2. Unlike cytosolic PGE synthase (cPGES) and microsomal ...