dio1 iodothyronine deiodinase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dio1provided by ZNC
Official Full Name: iodothyronine deiodinase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030328-41
See related: Ensembl:ENSDARG00000042112 AllianceGenome:ZFIN:ZDB-GENE-030328-41
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Deio1; cb685; zgc:92323
Summary: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (18039559..18042062, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (18003847..18006350, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the activities of iodothyronine deiodinase type (ID1) and iodothyronine deiodinase type (ID2) showed initially decreased and then increased trend, while the activity of iodothyronine deiodinase type (ID3) significantly decreased during microcystin -LR exposure.
Title: Waterborne exposure to microcystin-LR alters thyroid hormone levels, iodothyronine deiodinase activities, and gene transcriptions in juvenile zebrafish (Danio rerio).
Knockdown of D1+D2 (D1D2MO) and knockdown of D3 (D3MO) both resulted in transcriptional regulation of energy metabolism and (muscle) development in abdomen and tail
Title: Deiodinase knockdown during early zebrafish development affects growth, development, energy metabolism, motility and phototransduction.
This study investigated deiodinase 1 (Dio1), deiodinase 2 (Dio2), and deiodinase 3 (Dio3) mRNA expression at the several zebrafish life stages and found life stage specific expression of these genes that were highly localized.
Title: Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages.
role in zebrafish embryonic development
Title: Combined antisense knockdown of type 1 and type 2 iodothyronine deiodinases disrupts embryonic development in zebrafish (Danio rerio).

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables thyroxine 5'-deiodinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyroxine 5'-deiodinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hormone biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neural retina development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thyroid hormone metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: type I iodothyronine deiodinase

Names: deiodinase, iodothyronine, type I

NP_001007284.3

EC 1.21.99.4

NP_001311333.1

EC 1.21.99.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007283.2 → NP_001007284.3 type I iodothyronine deiodinase isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.

Source sequence(s)

BC155742, CD606655, CK864452, CO929563, CR847832, DN772220, EE331695, EH492365

UniProtKB/TrEMBL

A0A8M1N345, A9JRP6

Related

ENSDARP00000121555.1, ENSDART00000132596.2
NM_001324404.1 → NP_001311333.1 type I iodothyronine deiodinase isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon, which causes a frameshift compared to variant 1. The resulting isoform (2) is longer, with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AY221259, BC155742, CD606655, CO929563, CR847832, DN772220, EE331695, EH492365

UniProtKB/TrEMBL

A0A8M1P8S9, Q802F6