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ccnd2a cyclin D2, a [ Danio rerio (zebrafish) ]

Gene ID: 799608, updated on 27-Mar-2024

Summary

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Official Symbol
ccnd2aprovided by ZNC
Official Full Name
cyclin D2, aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070424-30
See related
Ensembl:ENSDARG00000051748 AllianceGenome:ZFIN:ZDB-GENE-070424-30
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:162280; gb:bi671621
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition; positive regulation of G1/S transition of mitotic cell cycle; and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in pharyngeal arch and testis. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; invasive lobular carcinoma; prostate cancer; and transitional cell carcinoma. Orthologous to human CCND2 (cyclin D2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ccnd2a in Genome Data Viewer
Location:
chromosome: 25
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (16970575..17239067, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (16874183..17142672, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438384 Neighboring gene uncharacterized LOC100537842 Neighboring gene TP53 induced glycolysis regulatory phosphatase a Neighboring gene lysine (K)-specific demethylase 7Ab Neighboring gene CCR4-NOT transcription complex, subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma. Chen EY, et al. PLoS Genet, 2013 Aug. PMID 24009521, Free PMC Article
  2. Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma. Tenente IM, et al. Elife, 2017 Jan 12. PMID 28080960, Free PMC Article
  3. Zebrafish cyclin Dx is required for development of motor neuron progenitors, and its expression is regulated by hypoxia-inducible factor 2α. Lien HW, et al. Sci Rep, 2016 Jun 21. PMID 27323909, Free PMC Article
  4. Protective effects of resveratrol against the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. Huang Y, et al. Toxicology, 2021 Mar 30. PMID 33524428
  5. Gon4l/Udu regulates cardiomyocyte proliferation and maintenance of ventricular chamber identity during zebrafish development. Budine TE, et al. Dev Biol, 2020 Jun 15. PMID 32272116, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G1/S-specific cyclin-D2; G1/S-specific cyclin-D2a
Names
ccnd2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089445.1 → NP_001082914.1  G1/S-specific cyclin-D2a

    See identical proteins and their annotated locations for NP_001082914.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133931
    UniProtKB/TrEMBL
    A3KNN7
    Related
    ENSDARP00000067910.5, ENSDART00000073419.7
    Conserved Domains (2) summary
    pfam00134
    Location:26 → 152
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:154 → 257
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    16970575..17239067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005174351.3 → XP_005174408.1  G1/S-specific cyclin-D2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BLM1
    Conserved Domains (2) summary
    pfam00134
    Location:1 → 72
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:74 → 177
    Cyclin_C; Cyclin, C-terminal domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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