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sqlea squalene epoxidase a [ Danio rerio (zebrafish) ]

Gene ID: 799528, updated on 27-Mar-2024

Summary

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Official Symbol
sqleaprovided by ZNC
Official Full Name
squalene epoxidase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-071004-98
See related
Ensembl:ENSDARG00000079946 AllianceGenome:ZFIN:ZDB-GENE-071004-98
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:171801
Summary
Predicted to enable squalene monooxygenase activity. Predicted to be involved in cholesterol metabolic process and sterol biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SQLE (squalene epoxidase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (43401005..43413297)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (43497263..43509555)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zmp:0000000930 Neighboring gene coiled-coil domain containing 127a Neighboring gene ring finger protein 144B Neighboring gene uncharacterized LOC110438000 Neighboring gene uncharacterized LOC103908977 Neighboring gene oxidation resistance 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Persistent Effects of Developmental Exposure to 17α-Ethinylestradiol on the Zebrafish (Danio rerio) Brain Transcriptome and Behavior. Porseryd T, et al. Front Behav Neurosci, 2017. PMID 28473760, Free PMC Article
  2. Multi-Dimensional Transcriptome Analysis Reveals Modulation of Cholesterol Metabolism as Highly Integrated Response to Brain Injury. Gourain V, et al. Front Neurosci, 2021. PMID 34054419, Free PMC Article
  3. 0# Diesel water-accommodated fraction induced lipid homeostasis alteration in zebrafish embryos. Mu X, et al. Environ Pollut, 2018 Nov. PMID 30373040
  4. Myclobutanil developmental toxicity, bioconcentration and sex specific response in cholesterol in zebrafish (Denio rerio). Pang S, et al. Chemosphere, 2020 Mar. PMID 31677519
  5. Sex specific response in cholesterol level in zebrafish (Danio rerio) after long-term exposure of difenoconazole. Mu X, et al. Environ Pollut, 2015 Feb. PMID 25483594

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables squalene monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables squalene monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
squalene monooxygenase
NP_001103509.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110039.1 → NP_001103509.1  squalene monooxygenase

    See identical proteins and their annotated locations for NP_001103509.1

    Status: PROVISIONAL

    Source sequence(s)
    BC153318
    UniProtKB/TrEMBL
    A8E4T1
    Related
    ENSDARP00000098511.2, ENSDART00000110994.5
    Conserved Domains (2) summary
    COG0654
    Location:109 → 482
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    cl21454
    Location:261 → 530
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    43401005..43413297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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