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lpin1a lipin 1a [ Danio rerio (zebrafish) ]

Gene ID: 799099, updated on 27-Mar-2024

Summary

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Official Symbol
lpin1aprovided by ZNC
Official Full Name
lipin 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080722-2
See related
Ensembl:ENSDARG00000020239 AllianceGenome:ZFIN:ZDB-GENE-080722-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lpin1; zgc:194552; zgc:194558
Summary
Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; fatty acid catabolic process; and triglyceride biosynthetic process. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be active in mitochondrial outer membrane and nucleus. Orthologous to human LPIN1 (lipin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (30442730..30470264)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (30425745..30453301)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108179775 Neighboring gene uncharacterized LOC108179777 Neighboring gene intersectin 2b Neighboring gene profilin family member 4 Neighboring gene NHS-like 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Enhancer selection dictates gene expression responses in remote organs during tissue regeneration. Sun F, et al. Nat Cell Biol, 2022 May. PMID 35513710, Free PMC Article
  2. Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition. Sapp V, et al. Hepatology, 2014 Nov. PMID 25043405
  3. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Gut P, et al. Nat Chem Biol, 2013 Feb. PMID 23201900, Free PMC Article
  4. Identification of Scd5 as a functional regulator of visceral fat deposition and distribution. Zhang Q, et al. iScience, 2022 Mar 18. PMID 35252813, Free PMC Article
  5. Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function. Manesia JK, et al. Stem Cells Dev, 2017 Apr 15. PMID 27958775, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidate phosphatase LPIN1
Names
lipin 1
NP_001037818.1
XP_005158866.1
XP_005158867.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044353.1 → NP_001037818.1  phosphatidate phosphatase LPIN1

    See identical proteins and their annotated locations for NP_001037818.1

    Status: PROVISIONAL

    Source sequence(s)
    AY822039
    UniProtKB/TrEMBL
    Q14EB8
    Related
    ENSDARP00000095032.2, ENSDART00000104257.4
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:633 → 858
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:473 → 563
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    30442730..30470264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158809.4 → XP_005158866.1  phosphatidate phosphatase LPIN1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B5S6, X1WH54
    Related
    ENSDARP00000129564.1, ENSDART00000155264.3
    Conserved Domains (3) summary
    pfam04571
    Location:27 → 132
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:659 → 884
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:499 → 589
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  2. XM_005158810.4 → XP_005158867.1  phosphatidate phosphatase LPIN1 isoform X2

    See identical proteins and their annotated locations for XP_005158867.1

    UniProtKB/TrEMBL
    B3DIU0, B3DIU6, F6NIT2
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:633 → 858
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:473 → 563
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394996.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    75724..93979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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