itgb7 integrin, beta 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itgb7provided by ZNC
Official Full Name: integrin, beta 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-100728-2
See related: Ensembl:ENSDARG00000044318 AllianceGenome:ZFIN:ZDB-GENE-100728-2
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin complex. Predicted to be active in cell surface and focal adhesion. Orthologous to human ITGB7 (integrin subunit beta 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (39702634..39737286, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (39705595..39739529, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin beta-7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

39702634..39737286 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477222.1 → XP_021332897.1 integrin beta-7

UniProtKB/TrEMBL

A0A8M9PN37

Related

ENSDARP00000065056.4, ENSDART00000065057.7

Conserved Domains (2) summary

pfam08725
Location:709 → 750

Integrin_b_cyt; Integrin beta cytoplasmic domain

cl00057
Location:33 → 454

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394662.1 Reference GRCz11 ALT_DRER_TU_1

Range

274798..304676 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021471830.1 → XP_021327505.1 integrin beta-7

UniProtKB/TrEMBL

A0A8M9Q259

Conserved Domains (3) summary

pfam07974
Location:580 → 609

EGF_2; EGF-like domain

pfam08725
Location:709 → 750

Integrin_b_cyt; Integrin beta cytoplasmic domain

cl00057
Location:33 → 454

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Reference GRCz11 ALT_DRER_TU_2

Genomic

NW_018395261.1 Reference GRCz11 ALT_DRER_TU_2

Range

182775..210056 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474125.1 → XP_021329800.1 integrin beta-7

UniProtKB/TrEMBL

A0A8M9Q931

Conserved Domains (3) summary

pfam07974
Location:507 → 534

EGF_2; EGF-like domain

pfam08725
Location:709 → 750

Integrin_b_cyt; Integrin beta cytoplasmic domain

cl00057
Location:33 → 454

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Reference GRCz11 ALT_DRER_TU_3

Genomic

NW_018395382.1 Reference GRCz11 ALT_DRER_TU_3

Range

48289..82941 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001337913.6 → XP_001337949.3 integrin beta-7

UniProtKB/TrEMBL

A0A8M9PN37

Conserved Domains (2) summary

pfam08725
Location:709 → 750

Integrin_b_cyt; Integrin beta cytoplasmic domain

cl00057
Location:33 → 454

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...