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espl1 extra spindle pole bodies like 1, separase [ Danio rerio (zebrafish) ]

Gene ID: 797406, updated on 27-Mar-2024

Summary

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Official Symbol
espl1provided by ZNC
Official Full Name
extra spindle pole bodies like 1, separaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5188
See related
Ensembl:ENSDARG00000075354 AllianceGenome:ZFIN:ZDB-GENE-030131-5188
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
espl1,; fl55e11; wu:fl55e11; mp:zf637-3-001691
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in meiotic chromosome separation. Predicted to act upstream of or within chromosome segregation and proteolysis. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Orthologous to human ESPL1 (extra spindle pole bodies like 1, separase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
32
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (39668853..39700911, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (39671375..39703352, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene La ribonucleoprotein 4Ab Neighboring gene prefoldin 5 Neighboring gene integrin, beta 7 Neighboring gene phosphofructokinase, muscle b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. Shepard JL, et al. Genes Dev, 2007 Jan 1. PMID 17210788, Free PMC Article
  2. A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Shepard JL, et al. Proc Natl Acad Sci U S A, 2005 Sep 13. PMID 16150706, Free PMC Article
  3. Zebrafish Hagoromo mutants up-regulate fgf8 postembryonically and develop neuroblastoma. Amsterdam A, et al. Mol Cancer Res, 2009 Jun. PMID 19531571, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic chromosome separation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
separin
Names
cease and desist
extra spindle pole bodies homolog 1
extra spindle poles like 1
separase
XP_001337869.1
XP_005166151.1
XP_021327503.1
XP_021327504.1
XP_021329798.1
XP_021329799.1
XP_021332895.1
XP_021332896.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    39668853..39700911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477221.1 → XP_021332896.1  separin isoform X2

    UniProtKB/TrEMBL
    A0A8M2BDI2
    Conserved Domains (1) summary
    pfam03568
    Location:1789 → 2129
    Peptidase_C50; Peptidase family C50

  2. XM_021477220.1 → XP_021332895.1  separin isoform X1

    UniProtKB/TrEMBL
    A0A8M1Q1L6, E7FDD8
    Related
    ENSDARP00000128879.1, ENSDART00000156645.2
    Conserved Domains (1) summary
    pfam03568
    Location:1790 → 2130
    Peptidase_C50; Peptidase family C50

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394662.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    242662..272517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471829.1 → XP_021327504.1  separin isoform X4

    UniProtKB/TrEMBL
    A0A8M9PRK1
    Conserved Domains (2) summary
    pfam03568
    Location:1746 → 2086
    Peptidase_C50; Peptidase family C50
    pfam11719
    Location:1274 → 1550
    Drc1-Sld2; DNA replication and checkpoint protein

  2. XM_021471828.1 → XP_021327503.1  separin isoform X3

    UniProtKB/TrEMBL
    A0A8M9PKI2
    Conserved Domains (2) summary
    pfam03568
    Location:1747 → 2087
    Peptidase_C50; Peptidase family C50
    pfam11719
    Location:1274 → 1550
    Drc1-Sld2; DNA replication and checkpoint protein

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395261.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    150348..181059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474124.1 → XP_021329799.1  separin isoform X2

    UniProtKB/TrEMBL
    A0A8M9PY30
    Conserved Domains (2) summary
    pfam03568
    Location:1788 → 2128
    Peptidase_C50; Peptidase family C50
    pfam11719
    Location:1316 → 1592
    Drc1-Sld2; DNA replication and checkpoint protein

  2. XM_021474123.1 → XP_021329798.1  separin isoform X1

    UniProtKB/TrEMBL
    A0A8M9PRZ2
    Conserved Domains (2) summary
    pfam03568
    Location:1789 → 2129
    Peptidase_C50; Peptidase family C50
    pfam11719
    Location:1316 → 1592
    Drc1-Sld2; DNA replication and checkpoint protein

Reference GRCz11 ALT_DRER_TU_3

Genomic

  1. NW_018395382.1 Reference GRCz11 ALT_DRER_TU_3

    Range
    14508..46566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166094.4 → XP_005166151.1  separin isoform X2

    UniProtKB/TrEMBL
    A0A8M2BDI2
    Conserved Domains (1) summary
    pfam03568
    Location:1789 → 2129
    Peptidase_C50; Peptidase family C50

  2. XM_001337833.5 → XP_001337869.1  separin isoform X1

    UniProtKB/TrEMBL
    A0A8M1Q1L6, E7FDD8
    Conserved Domains (1) summary
    pfam03568
    Location:1790 → 2130
    Peptidase_C50; Peptidase family C50
Nucleotide Protein Strain
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