cxcr2 chemokine (C-X-C motif) receptor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cxcr2provided by ZNC
Official Full Name: chemokine (C-X-C motif) receptor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-100414-1
See related: Ensembl:ENSDARG00000054975 AllianceGenome:ZFIN:ZDB-GENE-100414-1
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CXCR1bb; si:ch73-54b5.1
Summary: Enables granulocyte colony-stimulating factor binding activity. Acts upstream of or within defense response to bacterium; leukocyte migration; and neutrophil activation. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including digestive system; head; heart; intermediate cell mass of mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; human immunodeficiency virus infectious disease; pyelonephritis (multiple); and urinary tract infection. Orthologous to several human genes including CXCR2 (C-X-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (48108087..48109289)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (48410767..48411865)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables C-X-C chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables granulocyte colony-stimulating factor binding	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leukocyte migration involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain