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rbl1 retinoblastoma-like 1 (p107) [ Danio rerio (zebrafish) ]

Gene ID: 795522, updated on 27-Mar-2024

Summary

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Official Symbol
rbl1provided by ZNC
Official Full Name
retinoblastoma-like 1 (p107)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8179
See related
Ensembl:ENSDARG00000008141 AllianceGenome:ZFIN:ZDB-GENE-030131-8179
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj58e06; wu:fj58e06
Summary
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and negative regulation of G1/S transition of mitotic cell cycle. Predicted to act upstream of or within regulation of cell cycle; regulation of cell division; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in chromatin. Orthologous to human RBL1 (RB transcriptional corepressor like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (51548581..51574015, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (51549204..51573976, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type T Neighboring gene si:dkey-6e2.2 Neighboring gene chromodomain helicase DNA binding protein 6 Neighboring gene RIPOR family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Coordinate control of cell cycle regulatory genes in zebrafish development tested by cyclin D1 knockdown with morpholino phosphorodiamidates and hydroxyprolyl-phosphono peptide nucleic acids. Duffy KT, et al. Nucleic Acids Res, 2005. PMID 16284195, Free PMC Article
  2. Splice blocking of zygotic sox31 leads to developmental arrest shortly after Mid-Blastula Transition and induces apoptosis in zebrafish. Hu SN, et al. FEBS Lett, 2012 Feb 3. PMID 22209980
  3. High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis. Thomas HR, et al. PLoS One, 2014. PMID 25503746, Free PMC Article
  4. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
retinoblastoma-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130610.1 → NP_001124082.1  retinoblastoma-like protein 1

    See identical proteins and their annotated locations for NP_001124082.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162986
    UniProtKB/TrEMBL
    B3DI38
    Related
    ENSDARP00000068355.3, ENSDART00000073865.5
    Conserved Domains (4) summary
    pfam01857
    Location:771 → 932
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:386 → 579
    RB_A; Retinoblastoma-associated protein A domain
    pfam08934
    Location:951 → 1041
    Rb_C; Rb C-terminal domain
    pfam11934
    Location:79 → 210
    DUF3452; Domain of unknown function (DUF3452)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    51548581..51574015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476946.1 → XP_021332621.1  retinoblastoma-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QAH9
    Conserved Domains (4) summary
    pfam01857
    Location:771 → 924
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:386 → 579
    RB_A; Retinoblastoma-associated protein A domain
    pfam08934
    Location:943 → 1033
    Rb_C; Rb C-terminal domain
    pfam11934
    Location:79 → 210
    DUF3452; Domain of unknown function (DUF3452)
Nucleotide Protein
Heading Accession and Version

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