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plin2 perilipin 2 [ Danio rerio (zebrafish) ]

Gene ID: 794841, updated on 27-Mar-2024

Summary

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Official Symbol
plin2provided by ZNC
Official Full Name
perilipin 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050913-12
See related
Ensembl:ENSDARG00000042332 AllianceGenome:ZFIN:ZDB-GENE-050913-12
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
adfp; zgc:110411
Summary
Predicted to be involved in lipid storage and positive regulation of sequestering of triglyceride. Predicted to be active in cytosol and lipid droplet. Is expressed in digestive system. Orthologous to human PLIN2 (perilipin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See plin2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (17030820..17048868)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (17094606..17112775)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene yippee-like 2b Neighboring gene huntingtin interacting protein 1 Neighboring gene Ig-like domain-containing protein Neighboring gene CLPTM1 regulator of GABA type A receptor forward trafficking

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins. Zhang M, et al. Cancer Discov, 2018 Aug. PMID 29903879, Free PMC Article
  2. Imaging cytoplasmic lipid droplets in vivo with fluorescent perilipin 2 and perilipin 3 knock-in zebrafish. Wilson MH, et al. Elife, 2021 Aug 13. PMID 34387191, Free PMC Article
  3. An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish. Lumaquin D, et al. Elife, 2021 Jun 11. PMID 34114952, Free PMC Article
  4. Lipid droplet biology and evolution illuminated by the characterization of a novel perilipin in teleost fish. Granneman JG, et al. Elife, 2017 Feb 28. PMID 28244868, Free PMC Article
  5. Endoplasmic Reticulum Lipid Flux Influences Enterocyte Nuclear Morphology and Lipid-dependent Transcriptional Responses. Zeituni EM, et al. J Biol Chem, 2016 Nov 4. PMID 27655916, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC110411

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of sequestering of triglyceride IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
perilipin-2
Names
adipose differentiation-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030262.1 → NP_001025433.1  perilipin-2

    See identical proteins and their annotated locations for NP_001025433.1

    Status: PROVISIONAL

    Source sequence(s)
    BC096807
    UniProtKB/TrEMBL
    Q4V9M9
    Related
    ENSDARP00000143295.1, ENSDART00000175378.2
    Conserved Domains (1) summary
    pfam03036
    Location:6 → 394
    Perilipin; Perilipin family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    17030820..17048868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466286.1 → XP_021321961.1  perilipin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PIA4, F1QWT0
    Related
    ENSDARP00000110556.1, ENSDART00000129407.4
    Conserved Domains (1) summary
    pfam03036
    Location:22 → 410
    Perilipin; Perilipin family

  2. XM_021466287.1 → XP_021321962.1  perilipin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9P703
    Conserved Domains (1) summary
    pfam03036
    Location:8 → 290
    Perilipin; Perilipin family

  3. XM_021466288.1 → XP_021321963.1  perilipin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9P703
    Conserved Domains (1) summary
    pfam03036
    Location:8 → 290
    Perilipin; Perilipin family

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394943.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    154546..165901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395321.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    4432..12641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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