U.S. flag

An official website of the United States government

Clcnkb chloride voltage-gated channel Kb [ Rattus norvegicus (Norway rat) ]

Gene ID: 79430, updated on 4-Jan-2025

Summary

Official Symbol
Clcnkbprovided by RGD
Official Full Name
chloride voltage-gated channel Kbprovided by RGD
Primary source
RGD:628639
See related
EnsemblRapid:ENSRNOG00000009897 AllianceGenome:RGD:628639
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Clck2; ClC-K2L; Clcnk1l
Summary
This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 5. This gene is syntenic with human CLCNKA (geneID:1187).[provided by RefSeq, Sep 2009]
Expression
Biased expression in Kidney (RPKM 404.0) and Heart (RPKM 28.1) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Clcnkb in Genome Data Viewer
Location:
5q36
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (158993073..159005618, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153710086..153733162, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (159950384..159973576, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 131, member C Neighboring gene chloride voltage-gated channel Ka Neighboring gene heat shock protein family B (small) member 7 Neighboring gene transfer RNA proline (anticodon AGG) 71 Neighboring gene steroid receptor associated and regulated protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in chloride transmembrane transport  
involved_in chloride transport  
involved_in chloride transport PubMed 
involved_in regulation of intracellular pH  
involved_in regulation of intracellular pH  
involved_in renal absorption  
involved_in renal absorption  
involved_in renal absorption PubMed 
involved_in renal sodium ion absorption  
involved_in transepithelial chloride transport  
involved_in transepithelial chloride transport  
involved_in transepithelial chloride transport PubMed 
involved_in transepithelial chloride transport PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
part_of chloride channel complex  
is_active_in plasma membrane  

General protein information

Preferred Names
chloride channel protein ClC-Kb
Names
chloride channel K2
chloride channel Kb
chloride channel, voltage-sensitive Kb
clC-K2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173103.1NP_775126.1  chloride channel protein ClC-Kb

    See identical proteins and their annotated locations for NP_775126.1

    Status: PROVISIONAL

    Source sequence(s)
    Z30663
    UniProtKB/Swiss-Prot
    P51802
    UniProtKB/TrEMBL
    A6ITT3
    Related
    ENSRNOP00000082436.2, ENSRNOT00000101714.2
    Conserved Domains (3) summary
    cd03683
    Location:49533
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    pfam00571
    Location:547604
    CBS; CBS domain
    pfam00654
    Location:106513
    Voltage_CLC; Voltage gated chloride channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    158993073..159005618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288467.1XP_063144537.1  chloride channel protein ClC-Kb isoform X1

    UniProtKB/TrEMBL
    A6ITT2, A6ITT3
  2. XM_063288469.1XP_063144539.1  chloride channel protein ClC-Kb isoform X4

    UniProtKB/TrEMBL
    Q1W581
  3. XM_008764297.4XP_008762519.1  chloride channel protein ClC-Kb isoform X3

    UniProtKB/TrEMBL
    E9PTA8, Q1W581
    Related
    ENSRNOP00000049598.4, ENSRNOT00000050729.6
    Conserved Domains (2) summary
    cd03683
    Location:49490
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:503633
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
  4. XM_063288468.1XP_063144538.1  chloride channel protein ClC-Kb isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZU48, A6ITT3
External link. Please review our privacy policy.