sod3b superoxide dismutase 3, extracellular b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sod3bprovided by ZNC
Official Full Name: superoxide dismutase 3, extracellular bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8743
See related: Ensembl:ENSDARG00000079183 AllianceGenome:ZFIN:ZDB-GENE-030131-8743
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sod3; fb05f10; wu:fb05f10; si:dkey-117m1.6
Summary: Predicted to enable copper ion binding activity and superoxide dismutase activity. Predicted to be involved in removal of superoxide radicals. Predicted to act upstream of or within superoxide metabolic process. Is expressed in digestive system; female organism; and male organism. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Orthologous to human SOD3 (superoxide dismutase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (39990417..39992048)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (39272467..39273975)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Superoxide dismutase 3 is expressed in bone tissue and required for normal bone homeostasis and mineralization.
Title: Superoxide dismutase 3 is expressed in bone tissue and required for normal bone homeostasis and mineralization.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

fb05f10.x1 (e-PCR)
- UniSTS:202704

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within superoxide metabolic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: extracellular superoxide dismutase; extracellular superoxide dismutase [Cu-Zn]

XP_001332758.1

EC 1.15.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

39990417..39992048

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001332722.8 → XP_001332758.1 extracellular superoxide dismutase [Cu-Zn]

UniProtKB/TrEMBL

A0A8M1PYQ3, E9QIM2

Related

ENSDARP00000097881.2, ENSDART00000112150.4

Conserved Domains (1) summary

pfam00080
Location:55 → 185

Sod_Cu; Copper/zinc superoxide dismutase (SODC)