git2a G protein-coupled receptor kinase interacting ArfGAP 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: git2aprovided by ZNC
Official Full Name: G protein-coupled receptor kinase interacting ArfGAP 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060526-267
See related: Ensembl:ENSDARG00000061915 AllianceGenome:ZFIN:ZDB-GENE-060526-267
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: git2; si:dkey-234h16.4
Summary: Predicted to enable GTPase activator activity and metal ion binding activity. Acts upstream of or within cell migration involved in gastrulation and regulation of cell morphogenesis. Orthologous to human GIT2 (GIT ArfGAP 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (19885482..19932900, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (19381805..19429099, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development.
Title: The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ARF protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle recycling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ARF GTPase-activating protein GIT2; ARF GTPase-activating protein GIT2a

Names: G protein-coupled receptor kinase interactor 2; G protein-coupled receptor kinase interactor 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126453.1 → NP_001119925.1 ARF GTPase-activating protein GIT2a

Status: PROVISIONAL

Source sequence(s)

BX323811

UniProtKB/TrEMBL

A0A8M1NGT0, A2BG45

Related

ENSDARP00000083314.5, ENSDART00000088881.7

Conserved Domains (7) summary

smart00105
Location:12 → 134

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:147 → 230

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:276 → 304

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:630 → 744

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:147 → 239

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:424 → 488

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

sd00045
Location:147 → 175

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

19885482..19932900 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005165185.4 → XP_005165242.1 ARF GTPase-activating protein GIT2 isoform X2

UniProtKB/TrEMBL

A0A8M2BCH9

Conserved Domains (7) summary

smart00105
Location:12 → 134

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:147 → 230

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:276 → 304

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:630 → 796

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:147 → 239

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:424 → 488

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

sd00045
Location:147 → 175

ANK; ANK repeat [structural motif]
XM_009301359.3 → XP_009299634.1 ARF GTPase-activating protein GIT2 isoform X5

UniProtKB/TrEMBL

A0A8M3B2D0

Conserved Domains (7) summary

smart00105
Location:12 → 134

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:147 → 230

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:278 → 306

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:538 → 704

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:147 → 239

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:426 → 476

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

sd00045
Location:147 → 175

ANK; ANK repeat [structural motif]
XM_009301357.3 → XP_009299632.1 ARF GTPase-activating protein GIT2 isoform X3

UniProtKB/TrEMBL

A0A8M3ASB4

Conserved Domains (7) summary

smart00105
Location:12 → 134

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:147 → 230

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:278 → 306

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:632 → 746

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:147 → 239

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:426 → 490

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

sd00045
Location:147 → 175

ANK; ANK repeat [structural motif]
XM_005165184.4 → XP_005165241.1 ARF GTPase-activating protein GIT2 isoform X1

UniProtKB/TrEMBL

A0A8M2BCD7

Conserved Domains (7) summary

smart00105
Location:12 → 134

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:147 → 230

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08518
Location:278 → 306

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:632 → 798

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam12796
Location:147 → 239

Ank_2; Ankyrin repeats (3 copies)

pfam16559
Location:426 → 490

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

sd00045
Location:147 → 175

ANK; ANK repeat [structural motif]
XM_021476320.1 → XP_021331995.1 ARF GTPase-activating protein GIT2 isoform X4

UniProtKB/TrEMBL

A0A8M9QEB8

Conserved Domains (7) summary

smart00105
Location:12 → 134

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:147 → 230

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:147 → 175

ANK; ANK repeat [structural motif]

pfam08518
Location:278 → 305

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam12205
Location:632 → 668

GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term

pfam14203
Location:256 → 296

TTRAP; Putative tranposon-transfer assisting protein

pfam16559
Location:426 → 490

GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
XM_021476321.1 → XP_021331996.1 ARF GTPase-activating protein GIT2 isoform X6

UniProtKB/TrEMBL

A0A8M9Q912

Conserved Domains (5) summary

smart00105
Location:12 → 134

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:147 → 230

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:147 → 175

ANK; ANK repeat [structural motif]

pfam08518
Location:278 → 305

GIT_SHD; Spa2 homology domain (SHD) of GIT

pfam14203
Location:256 → 296

TTRAP; Putative tranposon-transfer assisting protein