hdc histidine decarboxylase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hdcprovided by ZNC
Official Full Name: histidine decarboxylaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080102-5
See related: Ensembl:ENSDARG00000075454 AllianceGenome:ZFIN:ZDB-GENE-080102-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable histidine decarboxylase activity. Acts upstream of or within chemical synaptic transmission; nervous system development; and response to light stimulus. Predicted to be active in cytoplasm. Is expressed in brain; caudal hypothalamic zone; hypothalamus; and posterior recess. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (73437..81640, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (73437..81635, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ethanol upregulates histidine decarboxylase expression in neural brain networks.
Title: Acute ethanol treatment upregulates Th1, Th2, and Hdc in larval zebrafish in stable networks.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables histidine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histidine decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amino acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within catecholamine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in histidine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: histidine decarboxylase

NP_001096063.1

EC 4.1.1.22

XP_005169965.1

EC 4.1.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102593.1 → NP_001096063.1 histidine decarboxylase

See identical proteins and their annotated locations for NP_001096063.1

Status: PROVISIONAL

Source sequence(s)

EF150846

UniProtKB/TrEMBL

A7KBS5

Related

ENSDARP00000124929.1, ENSDART00000149810.2

Conserved Domains (1) summary

pfam00282
Location:35 → 400

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

73437..81640 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005169908.4 → XP_005169965.1 histidine decarboxylase isoform X1

UniProtKB/TrEMBL

A0A8M2BH77

Conserved Domains (1) summary

pfam00282
Location:35 → 414

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain