Aco2 aconitase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aco2provided by RGD
Official Full Name: aconitase 2provided by RGD
Primary source: RGD:621360
See related: Ensembl:ENSRNOG00000024128 AllianceGenome:RGD:621360
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 3 iron, 4 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and aconitate hydratase activity. Involved in several processes, including response to isolation stress; tricarboxylic acid cycle; and tricarboxylic acid metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 5609.7), Muscle (RPKM 4060.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (115265816..115308931)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (113385677..113428794)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (123102493..123145608)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of acute kidney injury by WGCNA.
Title: Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of acute kidney injury by WGCNA.
Ogg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.
Title: Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells.
These results demonstrate the regulation of mitochondrial aconitase activity by protein kinase C-dependent phosphorylation.
Title: Regulation of mitochondrial aconitase by phosphorylation in diabetic rat heart.
Data suggest that an increase of transglutaminase 2 activity in Huntington disease caudate may contribute to mitochondrial dysfunction by incorporating aconitase into inactive polymers.
Title: Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain.
Induction of aconitate hydratase in hepatocytes of starving rats.
Title: Induction of aconitate hydratase in hepatocytes of starving rats.
Data show that the generation of potent reactive oxygen species (hydroxyl radicals) in cardiac H9c2 cells is attenuated by heat shock treatment.
Title: Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells.
frataxin is an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation
Title: Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134577 (e-PCR)
- UniSTS:217857

Aco2 (e-PCR), detects polymorphism
- UniSTS:506703

BF392697 (e-PCR)
- UniSTS:243575

Aco2 (e-PCR), detects polymorphism
- UniSTS:141004

D10Wsu183e (e-PCR), detects polymorphism
- UniSTS:141527

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3 iron, 4 sulfur cluster binding	IDA Inferred from Direct Assay more info	PubMed
enables 4 iron, 4 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 4 iron, 4 sulfur cluster binding	IDA Inferred from Direct Assay more info	PubMed
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables aconitate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aconitate hydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables aconitate hydratase activity	IEA Inferred from Electronic Annotation more info
enables aconitate hydratase activity	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in citrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within citrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in isocitrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to isolation stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tricarboxylic acid cycle	ISO Inferred from Sequence Orthology more info
involved_in tricarboxylic acid cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aconitate hydratase, mitochondrial

Names: aconitase 2, mitochondrial; citrate hydro-lyase; mitochondrial aconitase (nuclear aco2 gene)

NP_077374.2

EC 4.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.