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Serpind1 serpin family D member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79224, updated on 5-Mar-2024

Summary

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Official Symbol
Serpind1provided by RGD
Official Full Name
serpin family D member 1provided by RGD
Primary source
RGD:619854
See related
Ensembl:ENSRNOG00000001865 AllianceGenome:RGD:619854
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
rls2var1
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in heparin cofactor II deficiency. Orthologous to human SERPIND1 (serpin family D member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 3375.1) See more
Orthologs
human mouse all
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Genomic context

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Location:
11q23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (97168753..97179830, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83664517..83675593, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87913814..87924880, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene synaptosome associated protein 29 Neighboring gene uncharacterized LOC134481103 Neighboring gene phosphatidylinositol 4-kinase alpha Neighboring gene transmembrane protein 191C Neighboring gene HIC ZBTB transcriptional repressor 2 Neighboring gene 60S ribosomal protein L37 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular and cellular basis for type I heparin cofactor II deficiency (heparin cofactor II Awaji). Kondo S, et al. Blood, 1996 Feb 1. PMID 8562924
  2. Secondary thrombin-binding site, glycosaminoglycan binding domain and reactive center region of leuserpin-2 are strongly conserved in mammalian species. Westrup D, et al. Biochim Biophys Acta, 1994 Jan 18. PMID 8286422
  3. Plasma levels of heparin cofactor II (HCII) and thrombin-HCII complex in patients with disseminated intravascular coagulation. Noda A, et al. Clin Appl Thromb Hemost, 2002 Jul. PMID 12361205
  4. A novel missense mutation in the human plasmin inhibitor (alpha2-antiplasmin) gene associated with a bleeding tendency. Lind B, et al. Br J Haematol, 1999 Nov. PMID 10583218
  5. Inhibitors of fibrinolysis are elevated in atherosclerotic plaque. Robbie LA, et al. Arterioscler Thromb Vasc Biol, 1996 Apr. PMID 8624776

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heparin cofactor 2
Names
HC-II
heparin cofactor II
leuserpin 2
protease inhibitor leuserpin-2
serine (or cysteine) peptidase inhibitor, clade D, member 1
serine (or cysteine) proteinase inhibitor, clade D, member 1
serpin D1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024382.1 → NP_077358.1  heparin cofactor 2 precursor

    See identical proteins and their annotated locations for NP_077358.1

    Status: PROVISIONAL

    Source sequence(s)
    X74549
    UniProtKB/Swiss-Prot
    Q5BKA6, Q64268
    UniProtKB/TrEMBL
    A0A0G2K8K3, A6JSM3
    Related
    ENSRNOP00000031829.4, ENSRNOT00000031819.6
    Conserved Domains (1) summary
    cd02047
    Location:44 → 477
    HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    97168753..97179830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248709.4 → XP_006248771.1  heparin cofactor 2 isoform X1

    See identical proteins and their annotated locations for XP_006248771.1

    UniProtKB/Swiss-Prot
    Q5BKA6, Q64268
    UniProtKB/TrEMBL
    A0A0G2K8K3, A6JSM3
    Related
    ENSRNOP00000074639.2
    Conserved Domains (1) summary
    cd02047
    Location:44 → 477
    HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64268.1 GenPept UniProtKB/Swiss-Prot:Q64268

Gene LinkOut

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