Gng5 G protein subunit gamma 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gng5provided by RGD
Official Full Name: G protein subunit gamma 5provided by RGD
Primary source: RGD:620807
See related: AllianceGenome:RGD:620807
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G-protein beta-subunit binding activity and PDZ domain binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation and positive regulation of secondary heart field cardioblast proliferation. Part of G-protein beta/gamma-subunit complex. Orthologous to human GNG5 (G protein subunit gamma 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 585.4), Muscle (RPKM 539.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (238054954..238063451)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (235394680..235403177)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (252359976..252368473)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Gng5 (e-PCR), detects polymorphism
- UniSTS:496687

AA859354 (e-PCR)
- UniSTS:261174

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within positive regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of secondary heart field cardioblast proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of G-protein beta/gamma-subunit complex	IDA Inferred from Direct Assay more info	PubMed
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Names: G protein gamma-5 subunit; guanine nucleotide binding protein (G protein), gamma 5 subunit; guanine nucleotide binding protein gamma 5

NP_077353.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024377.2 → NP_077353.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

See identical proteins and their annotated locations for NP_077353.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P63219

UniProtKB/TrEMBL

F2Z3T8

Conserved Domains (1) summary

cd00068
Location:7 → 63

GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors