wnt16 wingless-type MMTV integration site family, member 16 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wnt16provided by ZNC
Official Full Name: wingless-type MMTV integration site family, member 16provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2330
See related: Ensembl:ENSDARG00000094973 AllianceGenome:ZFIN:ZDB-GENE-040426-2330
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77293
Summary: Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within several processes, including embryonic skeletal joint development; hematopoietic stem cell differentiation; and regulation of hematopoietic stem cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in central nervous system; myotome; neural tube; otic vesicle; and somite. Orthologous to human WNT16 (Wnt family member 16). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (10706618..10714555)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (10707209..10714735)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rspo1 is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC specification: Wnt16/DeltaC/DeltaD and Vegfa/Tgfbeta1
Title: R-spondin 1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways.
Wnt16 controls a novel genetic regulatory network required for HSC specification
Title: A somitic Wnt16/Notch pathway specifies haematopoietic stem cells.
genomic analysis of conserved sequences between human, rat, and zebrafish WNT16
Title: Comparative genomics on Wnt16 orthologs.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic skeletal joint development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100046.1 → NP_001093516.1 protein Wnt-16 precursor

Status: PROVISIONAL

Source sequence(s)

CT025718

UniProtKB/TrEMBL

A0A8M1NE17, A5WVL3

Related

ENSDARP00000122572.1, ENSDART00000132453.2

Conserved Domains (1) summary

pfam00110
Location:51 → 356

wnt; wnt family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

10706618..10714555

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164667.4 → XP_005164724.1 protein Wnt-16 isoform X1

UniProtKB/TrEMBL

A0A2R8S090, A0A8M2BBW0

Conserved Domains (1) summary

pfam00110
Location:1 → 239

wnt; wnt family