hmox1a heme oxygenase 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hmox1aprovided by ZNC
Official Full Name: heme oxygenase 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3102
See related: Ensembl:ENSDARG00000027529 AllianceGenome:ZFIN:ZDB-GENE-030131-3102
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hmox1; fc27c04; zgc:65984; wu:fc27c04
Summary: Enables heme oxygenase (decyclizing) activity. Acts upstream of or within cellular response to xenobiotic stimulus; regulation of respiratory gaseous exchange; and response to hypoxia. Is expressed in several structures, including heart; hematopoietic system; liver and biliary system; neuroepithelial cell; and solid lens vesicle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Orthologous to human HMOX1 (heme oxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (26011482..26017592, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (25880611..25886721, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Haem oxygenase limits Mycobacterium marinum infection-induced detrimental ferrostatin-sensitive cell death in zebrafish.
Title: Haem oxygenase limits Mycobacterium marinum infection-induced detrimental ferrostatin-sensitive cell death in zebrafish.
this study provides a better understanding of the role of the HO-1/Carbon monoxide system in controlling heart function in lower vertebrates.
Title: Evidence for a role of heme oxygenase-1 in the control of cardiac function in zebrafish (Danio rerio) larvae exposed to hypoxia.
The induced expression of HO-1 by fenofibrate appeared to be essential for mediating the protective effects of fenofibrate, as the inhibition of HO-1 activity significantly diminished the protective effects of fenofibrate against the GM-mediated death of sensory hair cells in cochlea
Title: Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes.
Suggest that Gata-1 and Nrf2a play differential roles in regulating the heme degradation enzymes hmox1a/bvra/bvrb during an early developmental period of heightened cellular stress.
Title: Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress.
Bach1 regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue.
Title: Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1.

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General gene information

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Markers

fb34a06.x1 (e-PCR)
- UniSTS:203129

fc27c04.x1 (e-PCR)
- UniSTS:187875

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme oxygenase (decyclizing) activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme oxygenase (decyclizing) activity	IEA Inferred from Electronic Annotation more info
enables heme oxygenase (decyclizing) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in heme catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme oxidation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heme oxidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of macrophage migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of respiratory gaseous exchange	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heme oxygenase 1a

Names: heme oxygenase (decycling) 1; heme oxygenase (decycling) 1a

NP_001120988.1

EC 1.4.9.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.