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Car14 carbonic anhydrase 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 791259, updated on 13-Apr-2024

Summary

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Official Symbol
Car14provided by RGD
Official Full Name
carbonic anhydrase 14provided by RGD
Primary source
RGD:1599277
See related
Ensembl:ENSRNOG00000023162 AllianceGenome:RGD:1599277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ca14
Summary
Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human CA14 (carbonic anhydrase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 233.9), Muscle (RPKM 182.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186131196..186138164, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183442263..183449231, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198010142..198017635, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene circadian associated repressor of transcription Neighboring gene similar to human chromosome 1 open reading frame 54 Neighboring gene aph-1 homolog A, gamma secretase subunit Neighboring gene small nucleolar RNA SNORA48 Neighboring gene acidic nuclear phosphoprotein 32 family member E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum. Akiba Y, et al. Gastroenterology, 2006 Jul. PMID 16831598
  2. Region- and cell-specific differences in the distribution of carbonic anhydrases II, III, XII, and XIV in the adult rat epididymis. Hermo L, et al. J Histochem Cytochem, 2005 Jun. PMID 15928319
  3. Localization of carbonic anhydrase XII to the basolateral membrane of H+-secreting cells of mouse and rat kidney. Kyllönen MS, et al. J Histochem Cytochem, 2003 Sep. PMID 12923247
  4. Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes. Whittington DA, et al. J Biol Chem, 2004 Feb 20. PMID 14660577
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonate dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carbonic anhydrase 14
Names
carbonic anhydrase XIV
NP_001103125.1
XP_006233052.1
XP_038959119.1
XP_063138677.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109655.3 → NP_001103125.1  carbonic anhydrase 14 precursor

    See identical proteins and their annotated locations for NP_001103125.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6GAJ9, A2IBE0
    Related
    ENSRNOP00000025523.6, ENSRNOT00000025523.7
    Conserved Domains (1) summary
    cd03126
    Location:29 → 278
    alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    186131196..186138164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103191.1 → XP_038959119.1  carbonic anhydrase 14 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8W4
    Conserved Domains (1) summary
    cd03126
    Location:20 → 269
    alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...

  2. XM_006232990.4 → XP_006233052.1  carbonic anhydrase 14 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8W4
    Related
    ENSRNOP00000087858.1, ENSRNOT00000105035.1
    Conserved Domains (1) summary
    cd03126
    Location:20 → 269
    alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...

  3. XM_063282607.1 → XP_063138677.1  carbonic anhydrase 14 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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