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PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 [ Gallus gallus (chicken) ]

Gene ID: 771142, updated on 5-Mar-2024

Summary

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Symbol
PIK3R2provided by CGNC
Full Name
phosphoinositide-3-kinase regulatory subunit 2provided by CGNC
Primary source
CGNC:2498
See related
Ensembl:ENSGALG00010027324
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 28
Exon count:
18
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 28 NC_052559.1 (4449537..4465469, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 28 NC_052600.1 (4011799..4027739, complement)

Chromosome 28 - NC_052559.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4C Neighboring gene RAB3A, member RAS oncogene family Neighboring gene MPV17 mitochondrial inner membrane protein like 2 Neighboring gene IFI30, lysosomal thiol reductase Neighboring gene microtubule associated serine/threonine kinase 3 Neighboring gene interleukin 12 receptor subunit beta 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3-kinase regulatory subunit beta
Names
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052559.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    4449537..4465469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001233340.7 → XP_001233341.3  phosphatidylinositol 3-kinase regulatory subunit beta

    UniProtKB/TrEMBL
    E1C2C5
    Related
    ENSGALP00010040506.1, ENSGALT00010066240.1
    Conserved Domains (5) summary
    cd09930
    Location:623 → 725
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:333 → 440
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11909
    Location:11 → 84
    SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12926
    Location:445 → 605
    iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
    cl02570
    Location:121 → 306
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  2. XM_040653788.2 → XP_040509722.1  phosphatidylinositol 3-kinase regulatory subunit beta

    UniProtKB/TrEMBL
    E1C2C5
    Conserved Domains (5) summary
    cd09930
    Location:623 → 725
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:333 → 440
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11909
    Location:11 → 84
    SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12926
    Location:445 → 605
    iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
    cl02570
    Location:121 → 306
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  3. XM_046904701.1 → XP_046760657.1  phosphatidylinositol 3-kinase regulatory subunit beta

    UniProtKB/TrEMBL
    E1C2C5

  4. XM_046904702.1 → XP_046760658.1  phosphatidylinositol 3-kinase regulatory subunit beta

    UniProtKB/TrEMBL
    E1C2C5

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052600.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    4011799..4027739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040692932.2 → XP_040548866.1  phosphatidylinositol 3-kinase regulatory subunit beta

    Conserved Domains (5) summary
    cd09930
    Location:623 → 725
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:333 → 440
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11909
    Location:11 → 84
    SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12926
    Location:445 → 605
    iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
    cl02570
    Location:121 → 306
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  2. XM_040692933.2 → XP_040548867.1  phosphatidylinositol 3-kinase regulatory subunit beta

    Conserved Domains (5) summary
    cd09930
    Location:623 → 725
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:333 → 440
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11909
    Location:11 → 84
    SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12926
    Location:445 → 605
    iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
    cl02570
    Location:121 → 306
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  3. XM_046933983.1 → XP_046789939.1  phosphatidylinositol 3-kinase regulatory subunit beta

  4. XM_046933984.1 → XP_046789940.1  phosphatidylinositol 3-kinase regulatory subunit beta

Nucleotide Protein
Heading Accession and Version

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