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CHEK2 checkpoint kinase 2 [ Gallus gallus (chicken) ]

Gene ID: 768913, updated on 3-Apr-2024

Summary

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Symbol
CHEK2provided by CGNC
Full Name
checkpoint kinase 2provided by CGNC
Primary source
CGNC:4245
See related
Ensembl:ENSGALG00010023822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
16
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 15 NC_052546.1 (7685326..7698687, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 15 NC_052587.1 (7695824..7709179, complement)

Chromosome 15 - NC_052546.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein beta Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene microRNA 1625 Neighboring gene uncharacterized LOC121106897 Neighboring gene microRNA 6650 Neighboring gene solute carrier family 2 member 11-like 5 Neighboring gene HscB mitochondrial iron-sulfur cluster cochaperone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase. Rainey MD, et al. Oncogene, 2008 Feb 7. PMID 17684483

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase Chk2
Names
CHK2 checkpoint homolog
checkpoint and tumor suppressor protein 2
NP_001073576.1
NP_001384598.1
XP_040504035.1
XP_046784221.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080107.2 → NP_001073576.1  serine/threonine-protein kinase Chk2 isoform 2

    See identical proteins and their annotated locations for NP_001073576.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000260
    UniProtKB/TrEMBL
    A0A8V0ZY48, A1EAT1, F1N864
    Related
    ENSGALP00010035288.1, ENSGALT00010058118.1
    Conserved Domains (2) summary
    cd00060
    Location:88 → 179
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:190 → 463
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

  2. NM_001397669.1 → NP_001384598.1  serine/threonine-protein kinase Chk2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000260
    Related
    ENSGALP00010035258.1, ENSGALT00010058080.1
    Conserved Domains (2) summary
    cd00060
    Location:88 → 179
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:190 → 463
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    7685326..7698687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040648101.2 → XP_040504035.1  serine/threonine-protein kinase Chk2 isoform X1

    Conserved Domains (1) summary
    cd14084
    Location:64 → 337
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

RNA

  1. XR_006931540.1 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052587.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    7695824..7709179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046928265.1 → XP_046784221.1  serine/threonine-protein kinase Chk2 isoform X1

RNA

  1. XR_006936303.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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