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cisha cytokine inducible SH2-containing protein a [ Danio rerio (zebrafish) ]

Gene ID: 767678, updated on 27-Mar-2024

Summary

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Official Symbol
cishaprovided by ZNC
Official Full Name
cytokine inducible SH2-containing protein aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050907-1
See related
Ensembl:ENSDARG00000060316 AllianceGenome:ZFIN:ZDB-GENE-050907-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cis; cish; ptk9l; twf1l; twf2a; cish.a; zgc:91817; wu:fk57g04; zgc:154062
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Acts upstream of or within negative regulation of erythrocyte differentiation; negative regulation of lymphocyte differentiation; and negative regulation of receptor signaling pathway via JAK-STAT. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in blastomere; pronephric duct; thymus; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (41503760..41506753)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (41506259..41509217)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene microRNA let7j Neighboring gene WD repeat domain 82 Neighboring gene twinfilin actin binding protein 2 Neighboring gene HemK methyltransferase family member 1 Neighboring gene SLIT-ROBO Rho GTPase activating protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Long-term effects of ionizing radiation on gene expression in a zebrafish model. Jaafar L, et al. PLoS One, 2013. PMID 23936019, Free PMC Article
  2. Fold-change threshold screening: a robust algorithm to unmask hidden gene expression patterns in noisy aggregated transcriptome data. Hausen J, et al. Environ Sci Pollut Res Int, 2015 Nov. PMID 26178833
  3. Hypoxia induces myocardial regeneration in zebrafish. Jopling C, et al. Circulation, 2012 Dec 18. PMID 23151342
  4. Prolactin controls branchial clcn2c but not atp1a1a.2 in zebrafish Danio rerio. Breves JP. J Fish Biol, 2019 Jan. PMID 30367725
  5. A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models. Loontiens S, et al. Leukemia, 2020 Dec. PMID 32591643, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC154062

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of lymphocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytokine-inducible SH2-containing protein
Names
twinfilin actin-binding protein 2a
twinfilin, actin-binding protein, homolog 1, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076617.2 → NP_001070085.1  cytokine-inducible SH2-containing protein

    See identical proteins and their annotated locations for NP_001070085.1

    Status: PROVISIONAL

    Source sequence(s)
    EF195760
    UniProtKB/TrEMBL
    B0EVP4, F6P797, Q08BW5
    Related
    ENSDARP00000079296.4, ENSDART00000084861.5
    Conserved Domains (2) summary
    cd10718
    Location:46 → 133
    SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
    cl02533
    Location:175 → 212
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    41503760..41506753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166065.3 → XP_005166122.1  cytokine-inducible SH2-containing protein isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDG1
    Related
    ENSDARP00000121026.1, ENSDART00000136538.3
    Conserved Domains (2) summary
    cd10718
    Location:42 → 129
    SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
    cl02533
    Location:171 → 208
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
Nucleotide Protein
Heading Accession and Version

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