Gpr17 G protein-coupled receptor 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Gpr17provided by RGD
Full Name: G protein-coupled receptor 17provided by RGD
Primary source: RGD:1589785
See related: Ensembl:ENSRNOG00000065480 AllianceGenome:RGD:1589785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables receptor serine/threonine kinase binding activity. Involved in oligodendrocyte differentiation. Predicted to be integral component of plasma membrane. Orthologous to human GPR17 (G protein-coupled receptor 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 65.2), Heart (RPKM 60.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (23850460..23857381, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (23576232..23583153, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (24733306..24739194, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of G protein-coupled receptor-17 (GPR17) facilitates the regeneration and repair of myelin sheath post-periventricular leukomalacia (PVL).
Title: Knockdown of G protein-coupled receptor-17 (GPR17) facilitates the regeneration and repair of myelin sheath post-periventricular leukomalacia (PVL).
Involvement of GPR17 in Neuronal Fibre Outgrowth.
Title: Involvement of GPR17 in Neuronal Fibre Outgrowth.
GPR17 plays a role in ischemia-induced endogenous repair of immature neonatal cerebral White matter.
Title: GPR17 plays a role in ischemia-induced endogenous repair of immature neonatal cerebral White matter.
These findings suggested that GPR17 may mediate ischemialike neuronal injury and microglial activation in vitro; however, the protective effects on ischemic neuronal injury might depend upon microglial activation.
Title: GPR17 mediates ischemia-like neuronal injury via microglial activation.
Montelukast reduces neuroinflammation, elevates hippocampal neurogenesis and improves learning and memory in old animals by inhibition of the GPR17 receptor.
Title: Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug.
Zhenbao pill could inhibit neuronal apoptosis by regulating miR-146a-5p/GPR17 expression, and then promoting the recovery of spinal cord function.
Title: Zhenbao pill protects against acute spinal cord injury via miR-146a-5p regulating the expression of GPR17.
These data show a co-localization between neuronal markers and GPR17 in vitro, and suggest that, besides its involvement in oligodendrogenesis, GPR17 can drive the fate of neural precursor cells by instructing precursors towards the neuronal lineage.
Title: A new role for the P2Y-like GPR17 receptor in the modulation of multipotency of oligodendrocyte precursor cells in vitro.
uracil nucleotides and cysteinyl leukotrienes do not activate human, mouse, or rat GPR17 in various cellular backgrounds.
Title: The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes.
stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein expression levels mainly by triggering the Galphai/o signaling pathway.
Title: The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules.
Data indicate that small molecule MDL29,951 activates human, mouse and rat orphan G protein-coupled receptor GPR17.
Title: Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uracil nucleotide/cysteinyl leukotriene receptor

Names: UDP/CysLT receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001071777.2 → NP_001065245.1 uracil nucleotide/cysteinyl leukotriene receptor

See identical proteins and their annotated locations for NP_001065245.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q09QM4

UniProtKB/TrEMBL

A6J2P8

Related

ENSRNOP00000091710.1, ENSRNOT00000104846.1

Conserved Domains (1) summary

cd15161
Location:32 → 308

7tmA_GPR17; G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors