Fads1 fatty acid desaturase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fads1provided by MGI
Official Full Name: fatty acid desaturase 1provided by MGI
Primary source: MGI:MGI:1923517
See related: Ensembl:ENSMUSG00000010663 AllianceGenome:MGI:1923517
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DSD; 0710001O03Rik; A930006B21Rik
Summary: Enables acyl-CoA delta5-desaturase activity. Predicted to be involved in arachidonic acid metabolic process and cellular response to starvation. Predicted to act upstream of or within long-chain fatty acid biosynthetic process and unsaturated fatty acid biosynthetic process. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Orthologous to human FADS1 (fatty acid desaturase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 116.7), liver adult (RPKM 83.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.54 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10160245..10174238)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10182877..10196874)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling.
Title: FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling.
Fads1 is an underappreciated regulator of inflammation initiation and resolution, and suggest that endogenously synthesized arachidonic acid and eicosapentaenoic acid are key determinates of inflammatory disease progression and liver X receptor signaling.
Title: Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators.
Data (including data from studies using knockout mice) suggest that increased dietary intake of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) differentially affects activity of D5D/Fads1 and D6D/Fads2 in specific tissues.
Title: Increasing dietary EPA and DHA influence estimated fatty acid desaturase activity in systemic organs which is reflected in the red blood cell in mice.
differential PUFA profiles between HET mice and human FADS SNPs suggest low expression of both FADS1 and 2 genes in human minor haplotypes.
Title: Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio.
Data indicate that delta-5 desaturase (D5D) inhibition was confirmed by determining changes in blood arachidonic acid/dihomo-gamma-linolenic acid (AA/DGLA) profiles.
Title: A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice.
knockdown of Elovl5, Fads1, or Fads2 decreased the level of Mead acid.
Title: Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency.
The Systemic disruption of the Fads1 gene reciprocally altered the levels of dihomo-gamma-linolenic acid and AA in mouse tissues, resulting in a profound increase in 1-series-derived and a concurrent decrease in 2-series-derived prostaglandins.
Title: Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model.
analysis of mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle
Title: mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle.
n-3 fatty acid desaturase may have a role in colitis-associated colon cancer in mice
Title: Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice.
support a significant role for reverse Delta5-desaturase as a natural antisense regulator of Delta5-desaturase
Title: A newly discovered member of the fatty acid desaturase gene family: a non-coding, antisense RNA gene to delta5-desaturase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (2)
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyl-CoA delta5-desaturase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acyl-CoA delta5-desaturase activity	ISO Inferred from Sequence Orthology more info
enables linoleoyl-CoA desaturase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within long-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within unsaturated fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in unsaturated fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acyl-CoA (8-3)-desaturase

Names: D5D; delta(5) desaturase; delta(5) fatty acid desaturase

NP_666206.1

EC 1.14.19.44

XP_006527501.1

EC 1.14.19.44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146094.2 → NP_666206.1 acyl-CoA (8-3)-desaturase

See identical proteins and their annotated locations for NP_666206.1

Status: VALIDATED

Source sequence(s)

AC132148, AK083959, BC063053

Consensus CDS

CCDS29572.1

UniProtKB/Swiss-Prot

Q3U494, Q8BZX7, Q8R0G8, Q8VC07, Q920L1

UniProtKB/TrEMBL

A0A494BBC6, X2EXD0

Related

ENSMUSP00000010807.5, ENSMUST00000010807.6

Conserved Domains (3) summary

PLN03199
Location:12 → 442

PLN03199; delta6-acyl-lipid desaturase-like protein; Provisional

cd03506
Location:164 → 415

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

pfam00173
Location:21 → 96

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

10160245..10174238

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527438.3 → XP_006527501.1 acyl-CoA (8-3)-desaturase isoform X1

Conserved Domains (1) summary

cd03506
Location:40 → 291

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...