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Snrnp35 small nuclear ribonucleoprotein 35 (U11/U12) [ Mus musculus (house mouse) ]

Gene ID: 76167, updated on 5-Mar-2024

Summary

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Official Symbol
Snrnp35provided by MGI
Official Full Name
small nuclear ribonucleoprotein 35 (U11/U12)provided by MGI
Primary source
MGI:MGI:1923417
See related
Ensembl:ENSMUSG00000029402 AllianceGenome:MGI:1923417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330548G22Rik
Summary
Predicted to enable mRNA binding activity and snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleolus. Predicted to be part of U12-type spliceosomal complex. Is expressed in several structures, including brain; central nervous system ganglion; and retina. Orthologous to human SNRNP35 (small nuclear ribonucleoprotein U11/U12 subunit 35). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 8.8), CNS E11.5 (RPKM 6.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Snrnp35 in Genome Data Viewer
Location:
5 F; 5 63.61 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124621099..124631649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124483081..124493586)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene lysine methyltransferase 5A Neighboring gene Rab interacting lysosomal protein-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E8082 Neighboring gene STARR-positive B cell enhancer ABC_E11302 Neighboring gene STARR-positive B cell enhancer ABC_E2178 Neighboring gene STARR-positive B cell enhancer ABC_E6382 Neighboring gene peptidylprolyl isomerase A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10352 Neighboring gene predicted gene, 52789 Neighboring gene Rab interacting lysosomal protein-like 1 Neighboring gene ribosomal protein L32 5C pseudogene Neighboring gene transmembrane p24 trafficking protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elevated U12-intron retention has been demonstrated in all examined tissues from spinal muscular atrophy mice.
    Title: RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U12-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U11/U12 small nuclear ribonucleoprotein 35 kDa protein
Names
U1 snRNP-binding protein homolog
U11/U12 snRNP 35 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029532.2 → NP_083808.1  U11/U12 small nuclear ribonucleoprotein 35 kDa protein

    See identical proteins and their annotated locations for NP_083808.1

    Status: PROVISIONAL

    Source sequence(s)
    BC043031
    Consensus CDS
    CCDS19677.1
    UniProtKB/Swiss-Prot
    Q8CAC7, Q9D384
    Related
    ENSMUSP00000031349.9, ENSMUST00000031349.9
    Conserved Domains (1) summary
    cd12237
    Location:48 → 137
    RRM_snRNP35; RNA recognition motif found in U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12-35K) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124621099..124631649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530495.5 → XP_006530558.1  U11/U12 small nuclear ribonucleoprotein 35 kDa protein isoform X1

    See identical proteins and their annotated locations for XP_006530558.1

    UniProtKB/Swiss-Prot
    Q8CAC7, Q9D384
    Conserved Domains (1) summary
    cd12237
    Location:48 → 137
    RRM_snRNP35; RNA recognition motif found in U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12-35K) and similar proteins

  2. XM_006530494.5 → XP_006530557.1  U11/U12 small nuclear ribonucleoprotein 35 kDa protein isoform X1

    See identical proteins and their annotated locations for XP_006530557.1

    UniProtKB/Swiss-Prot
    Q8CAC7, Q9D384
    Related
    ENSMUSP00000107080.2, ENSMUST00000111453.2
    Conserved Domains (1) summary
    cd12237
    Location:48 → 137
    RRM_snRNP35; RNA recognition motif found in U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12-35K) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D384.1 GenPept UniProtKB/Swiss-Prot:Q9D384

Gene LinkOut

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