Pik3r4 phosphoinositide-3-kinase regulatory subunit 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pik3r4provided by MGI
Official Full Name: phosphoinositide-3-kinase regulatory subunit 4provided by MGI
Primary source: MGI:MGI:1922919
See related: Ensembl:ENSMUSG00000032571 AllianceGenome:MGI:1922919
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p150; Vps15; D9Ertd418e; 2210010O15Rik; C730038E05Rik
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in cellular response to glucose starvation. Located in axoneme. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in central nervous system; embryo; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 8.1), spleen adult (RPKM 7.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 56.79 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (105520156..105564854)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (105642995..105687655)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that Mutations in Vps15 perturb neuronal migration in mice.
Title: Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.
Vps15-deficient mouse tissues are competent for LC3-positive autophagosome formation and maintain mTOR activation.
Title: Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_17559-17560:1030455059:1 (e-PCR)
- UniSTS:268342

D9Dcr82 (e-PCR), detects polymorphism
- UniSTS:499044

NoName (e-PCR)
- UniSTS:224392

C85833 (e-PCR)
- UniSTS:159917

RH126920 (e-PCR)
- UniSTS:167619

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in autophagy of peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucose starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in late endosome to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to lysosome	NAS Non-traceable Author Statement more info	PubMed
involved_in protein targeting to vacuole	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of macroautophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in nucleus-vacuole junction	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class III	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class III, type I	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III, type II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphoinositide 3-kinase regulatory subunit 4

Names: PI3-kinase regulatory subunit 4; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150

NP_001074778.1

EC 2.7.11.1

XP_036011263.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081309.1 → NP_001074778.1 phosphoinositide 3-kinase regulatory subunit 4

See identical proteins and their annotated locations for NP_001074778.1

Status: PROVISIONAL

Source sequence(s)

AC157514

Consensus CDS

CCDS40753.1

UniProtKB/Swiss-Prot

Q56A65, Q8C948, Q8C9D7, Q8VD65, Q9CVC5

UniProtKB/TrEMBL

B2RXR2

Related

ENSMUSP00000067400.7, ENSMUST00000065778.13

Conserved Domains (8) summary

smart00320
Location:1327 → 1358

WD40; WD40 repeats

COG2319
Location:991 → 1358

WD40; WD40 repeat [General function prediction only]

cd13980
Location:25 → 320

STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15

pfam00069
Location:26 → 309

Pkinase; Protein kinase domain

pfam07539
Location:352 → 449

DRIM; Down-regulated in metastasis

sd00044
Location:539 → 566

HEAT; HEAT repeat [structural motif]

sd00039
Location:997 → 1040

7WD40; WD40 repeat [structural motif]

cl02567
Location:985 → 1269

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

105520156..105564854

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155370.1 → XP_036011263.1 phosphoinositide 3-kinase regulatory subunit 4 isoform X1

UniProtKB/TrEMBL

B2RXR2

Conserved Domains (5) summary

smart00320
Location:1335 → 1366

WD40; WD40 repeats

cd13980
Location:25 → 320

STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15

sd00044
Location:539 → 566

HEAT; HEAT repeat [structural motif]

sd00039
Location:1005 → 1048

7WD40; WD40 repeat [structural motif]

cl29593
Location:993 → 1277

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_029380.1: Suppressed sequence

Description

NM_029380.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.