MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: MAP4K1provided by VGNC
Official Full Name: mitogen-activated protein kinase kinase kinase kinase 1provided by VGNC
Primary source: VGNC:VGNC:7488
Locus tag: CK820_G0030364
See related: Ensembl:ENSPTRG00000010933
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	20	NC_072418.2 (41718940..41747266, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	19	NC_072417.1 (41718968..41747148, complement)

Chromosome 20 - NC_072418.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

PMC156606P1 (e-PCR)
- UniSTS:271408

RH71249 (e-PCR)
- UniSTS:61819

GDB:182154 (e-PCR)
- UniSTS:155359

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables MAP kinase kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mitogen-activated protein kinase kinase kinase kinase 1

XP_003316364.1

EC 2.7.11.1

XP_009433814.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072418.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

41718940..41747266 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003316316.7 → XP_003316364.1 mitogen-activated protein kinase kinase kinase kinase 1 isoform X1

UniProtKB/TrEMBL

A0A2I3SN46, A0A2J8QF52, A0A2J8QF59, A0A6D2X7N9, A0A6D2XSF2, H2QG87

Related

ENSPTRP00000077941.1

Conserved Domains (2) summary

smart00036
Location:500 → 807

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cd06613
Location:16 → 274

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
XM_009435539.5 → XP_009433814.1 mitogen-activated protein kinase kinase kinase kinase 1 isoform X2

UniProtKB/TrEMBL

A0A2J8QF31

Related

ENSPTRP00000071600.1

Conserved Domains (3) summary

smart00036
Location:500 → 780

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:17 → 274

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06613
Location:16 → 274

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases