PTPN11 protein tyrosine phosphatase non-receptor type 11 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: PTPN11provided by VGNC
Official Full Name: protein tyrosine phosphatase non-receptor type 11provided by VGNC
Primary source: VGNC:VGNC:5553
Locus tag: CK820_G0015869
See related: Ensembl:ENSPTRG00000048264
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 10

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	10	NC_072408.2 (119251764..119345874)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	12	NC_072410.1 (117875846..117969937)

Chromosome 10 - NC_072408.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

SHGC-30316 (e-PCR)
- UniSTS:35867

WI-7628 (e-PCR)
- UniSTS:57652

WI-18740 (e-PCR)
- UniSTS:66916

RH78116 (e-PCR)
- UniSTS:23159

G34953 (e-PCR)
- UniSTS:117663

RH67010 (e-PCR)
- UniSTS:86484

Related pseudogene(s)

1 found Review record(s) in Gene

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IEA Inferred from Electronic Annotation more info	PubMed
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: tyrosine-protein phosphatase non-receptor type 11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

119251764..119345874

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016924286.4 → XP_016779775.2 tyrosine-protein phosphatase non-receptor type 11 isoform X3

UniProtKB/TrEMBL

A0A2J8MYH5, A0A8I3B2Z9, H2RIH8, K7B611, K7DQU5

Conserved Domains (3) summary

cd09931
Location:111 → 218

SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

cd10340
Location:5 → 103

SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

cd14605
Location:272 → 524

PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11
XM_063785017.1 → XP_063641087.1 tyrosine-protein phosphatase non-receptor type 11 isoform X1

UniProtKB/TrEMBL

A0A2J8MYK5, A0A8I3B413, K6ZR35, K7CNV8
XM_054663612.2 → XP_054519587.1 tyrosine-protein phosphatase non-receptor type 11 isoform X4
XM_063785018.1 → XP_063641088.1 tyrosine-protein phosphatase non-receptor type 11 isoform X2