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PTPN6 protein tyrosine phosphatase non-receptor type 6 [ Pan troglodytes (chimpanzee) ]

Gene ID: 748032, updated on 29-Mar-2024

Summary

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Official Symbol
PTPN6provided by VGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 6provided by VGNC
Primary source
VGNC:VGNC:5554
Locus tag
CK820_G0048122
See related
Ensembl:ENSPTRG00000004601
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 10 NC_072408.2 (14129084..14146585)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 12 NC_072410.1 (12778944..12796360)

Chromosome 10 - NC_072408.2Genomic Context describing neighboring genes Neighboring gene atrophin 1 Neighboring gene U7 small nuclear RNA Neighboring gene chromosome 12 C12orf57 homolog Neighboring gene uncharacterized LOC129136600 Neighboring gene microRNA mir-200c Neighboring gene microRNA mir-141

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 6
XP_001163468.2
XP_003313513.1
XP_063641496.1
XP_063641497.1
XP_063641498.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    14129084..14146585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001163468.6 → XP_001163468.2  tyrosine-protein phosphatase non-receptor type 6 isoform X1

    See identical proteins and their annotated locations for XP_001163468.2

    UniProtKB/TrEMBL
    A0A2J8JEF1, A0A2J8JEF6, A0A6D2VU38, H2R7K2
    Related
    ENSPTRP00000050501.4
    Conserved Domains (3) summary
    cd09931
    Location:111 → 217
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:6 → 103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd00047
    Location:274 → 516
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. XM_063785427.1 → XP_063641497.1  tyrosine-protein phosphatase non-receptor type 6 isoform X3

  3. XM_063785428.1 → XP_063641498.1  tyrosine-protein phosphatase non-receptor type 6 isoform X3

  4. XM_003313465.7 → XP_003313513.1  tyrosine-protein phosphatase non-receptor type 6 isoform X2

    See identical proteins and their annotated locations for XP_003313513.1

    UniProtKB/TrEMBL
    A0A2I3RC07, A0A2J8JEF6, A0A2J8JEF7, A0A6D2VTD8
    Related
    ENSPTRP00000062176.1
    Conserved Domains (3) summary
    cd09931
    Location:109 → 215
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:3 → 101
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14606
    Location:253 → 518
    PTPc-N6; catalytic domain of tyrosine-protein phosphatase non-receptor type 6

  5. XM_063785426.1 → XP_063641496.1  tyrosine-protein phosphatase non-receptor type 6 isoform X3

RNA

  1. XR_001707801.4 RNA Sequence

  2. XR_010147952.1 RNA Sequence

Nucleotide Protein
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