Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pik3cbprovided by MGI
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaprovided by MGI
Primary source: MGI:MGI:1922019
See related: Ensembl:ENSMUSG00000032462 AllianceGenome:MGI:1922019
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p110beta; 1110001J02Rik
Summary: Enables 1-phosphatidylinositol-3-kinase activity and insulin receptor substrate binding activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; regulation of intracellular signal transduction; and response to ischemia. Acts upstream of or within several processes, including angiogenesis involved in wound healing; embryonic cleavage; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in nucleus. Is expressed in several structures, including early embryo; genitourinary system; liver; respiratory system; and spleen. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 11.2), subcutaneous fat pad adult (RPKM 5.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 51.41 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (98920455..99022264, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (99038402..99140235, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PI3Kbeta controls immune evasion in PTEN-deficient breast tumours.
Title: PI3Kβ controls immune evasion in PTEN-deficient breast tumours.
SUMOylation modulates the stability and function of PI3K-p110beta.
Title: SUMOylation modulates the stability and function of PI3K-p110β.
Inactivation of endothelial cell phosphoinositide 3-kinase beta inhibits tumor angiogenesis and tumor growth.
Title: Inactivation of endothelial cell phosphoinositide 3-kinase β inhibits tumor angiogenesis and tumor growth.
macropinocytosis in response to receptor tyrosine kinase activation is strikingly dependent on a single class I PI3K isoform, namely PI3Kbeta (containing the p110beta catalytic subunit encoded by PIK3CB). Loss of PI3Kbeta expression or activity blocks macropinocytosis at early steps.
Title: PI3Kβ is selectively required for growth factor-stimulated macropinocytosis.
While the loss of endothelial PI3Kbeta activity produces cardioprotective effects, cardiac myocyte PI3Kbeta is protective against myocardial ischaemic injury.
Title: Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury.
The crucial role of p110beta and the more subtle role of p110alpha in the production of PIP3 molecular species following platelet stimulation has been demonstrated.
Title: Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation.
these results identify the PI3K-GSK3-SMAD1 axis as a central node integrating multiple signaling networks that govern bone formation and homeostasis.
Title: Class I PI-3-Kinase Signaling Is Critical for Bone Formation Through Regulation of SMAD1 Activity in Osteoblasts.
Collectively, these findings provide a mechanistic account of how Rac1-dependent membrane raft localization regulates differential activation of distinct phosphoinositide 3-kinase isoforms and offer insight into why PTEN-deficient cancers depend on p110beta.
Title: Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss.
p110beta transduces GPCR signals in the context of coincident activation by an RTK. The p110beta-Gbetagamma interaction was also required for neutrophils to generate reactive oxygen species in response to the Fcgamma receptor-dependent recognition of immune complexes
Title: Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells.
PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp gene by targeting BMAL1 and CLOCK.
Title: PI3K regulates BMAL1/CLOCK-mediated circadian transcription from the Dbp promoter.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (10) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125348 (e-PCR)
- UniSTS:162170

AI447572 (e-PCR)
- UniSTS:159912

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor substrate binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis involved in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic cleavage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Rac protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of neutrophil apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingosine-1-phosphate receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sphingosine-1-phosphate receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class IA	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Names: PI3-kinase subunit beta; PI3K-beta; PI3Kbeta; phosphatidylinositol 3-kinase, catalytic, beta polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; serine/threonine protein kinase PIK3CB

NP_083370.2

EC 2.7.1.153

EC 2.7.11.1

XP_011241131.1

EC 2.7.1.153

EC 2.7.11.1

XP_011241132.1

EC 2.7.1.153

EC 2.7.11.1

XP_030100548.1

EC 2.7.1.153

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029094.3 → NP_083370.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

See identical proteins and their annotated locations for NP_083370.2

Status: VALIDATED

Source sequence(s)

AK090116, CJ129150, CV558291

Consensus CDS

CCDS23432.1

UniProtKB/Swiss-Prot

Q3U4Q1, Q8BTI9

UniProtKB/TrEMBL

A0JNZ1

Related

ENSMUSP00000035037.8, ENSMUST00000035037.14

Conserved Domains (5) summary

cd08693
Location:318 → 495

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00143
Location:35 → 112

PI3K_p85B; PI3-kinase family, p85-binding domain

cd00872
Location:526 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05173
Location:700 → 1061

PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

pfam00794
Location:174 → 282

PI3K_rbd; PI3-kinase family, ras-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

98920455..99022264 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244688.2 → XP_030100548.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

UniProtKB/TrEMBL

A0JNZ1

Conserved Domains (4) summary

cd08693
Location:173 → 350

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

cd00872
Location:381 → 551

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05173
Location:555 → 916

PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

pfam00794
Location:29 → 137

PI3K_rbd; PI3-kinase family, ras-binding domain
XM_011242829.4 → XP_011241131.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

See identical proteins and their annotated locations for XP_011241131.1

UniProtKB/Swiss-Prot

Q3U4Q1, Q8BTI9

UniProtKB/TrEMBL

A0JNZ1

Conserved Domains (5) summary

cd08693
Location:318 → 495

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00143
Location:35 → 112

PI3K_p85B; PI3-kinase family, p85-binding domain

cd00872
Location:526 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05173
Location:700 → 1061

PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

pfam00794
Location:174 → 282

PI3K_rbd; PI3-kinase family, ras-binding domain
XM_011242830.4 → XP_011241132.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

See identical proteins and their annotated locations for XP_011241132.1

UniProtKB/Swiss-Prot

Q3U4Q1, Q8BTI9

UniProtKB/TrEMBL

A0JNZ1

Conserved Domains (5) summary

cd08693
Location:318 → 495

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00143
Location:35 → 112

PI3K_p85B; PI3-kinase family, p85-binding domain

cd00872
Location:526 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05173
Location:700 → 1061

PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

pfam00794
Location:174 → 282

PI3K_rbd; PI3-kinase family, ras-binding domain