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CRK CRK proto-oncogene, adaptor protein [ Pan troglodytes (chimpanzee) ]

Gene ID: 747142, updated on 29-Mar-2024

Summary

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Official Symbol
CRKprovided by VGNC
Official Full Name
CRK proto-oncogene, adaptor proteinprovided by VGNC
Primary source
VGNC:VGNC:12058
Locus tag
CK820_G0046729
See related
Ensembl:ENSPTRG00000045379
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 19 NC_072417.2 (11903805..11936067, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 17 NC_072415.1 (1966364..1998633)

Chromosome 19 - NC_072417.2Genomic Context describing neighboring genes Neighboring gene trafficking regulator of GLUT4 (SLC2A4) 1 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Neighboring gene myosin IC Neighboring gene uncharacterized LOC104002745 Neighboring gene inositol polyphosphate-5-phosphatase K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
adapter molecule crk
Names
v-crk sarcoma virus CT10 oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072417.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    11903805..11936067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016931123.4 → XP_016786612.1  adapter molecule crk isoform X2

    UniProtKB/TrEMBL
    A0A2J8JKJ9, A0A803KI03, G2HDY0, K7CUT5
    Conserved Domains (2) summary
    cd09926
    Location:5 → 122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135 → 189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

  2. XM_016931122.4 → XP_016786611.1  adapter molecule crk isoform X1

    UniProtKB/TrEMBL
    A0A2J8JKL2, A0A6D2WS42, K7D4Z8
    Related
    ENSPTRP00000083173.1
    Conserved Domains (3) summary
    cd09926
    Location:5 → 122
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:135 → 189
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    cd11759
    Location:237 → 293
    SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
Nucleotide Protein
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