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ADAM10 ADAM metallopeptidase domain 10 [ Pan troglodytes (chimpanzee) ]

Gene ID: 746942, updated on 29-Mar-2024

Summary

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Official Symbol
ADAM10provided by VGNC
Official Full Name
ADAM metallopeptidase domain 10provided by VGNC
Primary source
VGNC:VGNC:1570
Locus tag
CK820_G0008444
See related
Ensembl:ENSPTRG00000007116
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 16 NC_072414.2 (50609646..50760625, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 15 NC_072413.1 (50584510..50735472, complement)

Chromosome 16 - NC_072414.2Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL28-like Neighboring gene uncharacterized LOC104002321 Neighboring gene lipase C, hepatic type Neighboring gene small nucleolar RNA U13 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Neighboring gene putative heat shock protein HSP 90-beta 4 Neighboring gene small nucleolar RNA U3 Neighboring gene MINDY lysine 48 deubiquitinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 10
XP_001172405.1
XP_016783775.1
XP_063651124.1
XP_063651125.1
XP_063651126.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072414.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    50609646..50760625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001172405.6 → XP_001172405.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_001172405.1

    UniProtKB/TrEMBL
    A0A2I3RUF8, A0A2J8NSD1, A0A6D2XW77, H2Q9I4
    Related
    ENSPTRP00000012167.2
    Conserved Domains (3) summary
    smart00050
    Location:466 → 545
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:220 → 459
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:46 → 156
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_016928286.4 → XP_016783775.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X2

    UniProtKB/TrEMBL
    A0A2I3RUF8
    Conserved Domains (3) summary
    smart00050
    Location:435 → 514
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:220 → 428
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:43 → 156
    Pep_M12B_propep; Reprolysin family propeptide

  3. XM_063795055.1 → XP_063651125.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X3

  4. XM_063795056.1 → XP_063651126.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X4

  5. XM_063795054.1 → XP_063651124.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X3

Nucleotide Protein
Heading Accession and Version

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