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CASP8 caspase 8 [ Pan troglodytes (chimpanzee) ]

Gene ID: 746477, updated on 3-Apr-2024

Summary

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Official Symbol
CASP8provided by VGNC
Official Full Name
caspase 8provided by VGNC
Primary source
VGNC:VGNC:119
Locus tag
CK820_G0014830
See related
Ensembl:ENSPTRG00000012801
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2B
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 13 NC_072411.2 (103265594..103320609)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 2B NC_072400.1 (103266042..103318044)

Chromosome 13 - NC_072411.2Genomic Context describing neighboring genes Neighboring gene CASP8 and FADD like apoptosis regulator Neighboring gene large ribosomal subunit protein eL38-like Neighboring gene caspase 10 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene trafficking kinesin protein 2 Neighboring gene SCYL2 pseudogene 1 Neighboring gene STE20 related adaptor beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
caspase-8
Names
caspase 8, apoptosis-related cysteine peptidase
XP_001172193.1
XP_009442259.1
XP_009442260.1
XP_009442261.1
XP_009442262.1
XP_009442265.1
XP_009442266.1
XP_009442269.1
XP_009442270.1
XP_016805776.1
XP_016805777.1
XP_054535194.1
XP_054535195.1
XP_054535196.1
XP_063647605.1
XP_063647606.1
XP_063647608.1
XP_063647609.1
XP_063647610.1
XP_063647611.1
XP_063647612.1
XP_063647613.1
XP_063647614.1
XP_063647615.1
XP_063647616.1
XP_063647617.1
XP_063647618.1
XP_063647619.1
XP_063647620.1
XP_063647621.1
XP_063647622.1
XP_063647623.1
XP_063647624.1
XP_063647625.1
XP_063647626.1
XP_063647627.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072411.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    103265594..103320609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054679219.2 → XP_054535194.1  caspase-8 isoform X5

    UniProtKB/TrEMBL
    A0A2I3RN77, A0A2J8N566, A0A6D2WZ76

  2. XM_063791539.1 → XP_063647609.1  caspase-8 isoform X5

    UniProtKB/TrEMBL
    A0A2I3RN77, A0A2J8N566, A0A6D2WZ76

  3. XM_063791541.1 → XP_063647611.1  caspase-8 isoform X5

    UniProtKB/TrEMBL
    A0A2I3RN77, A0A2J8N566, A0A6D2WZ76

  4. XM_063791535.1 → XP_063647605.1  caspase-8 isoform X4

    UniProtKB/TrEMBL
    A0A2I3T6Z1, A0A2J8N557, A0A6D2VYS4

  5. XM_063791552.1 → XP_063647622.1  caspase-8 isoform X12

  6. XM_063791545.1 → XP_063647615.1  caspase-8 isoform X7

  7. XM_009443990.5 → XP_009442265.1  caspase-8 isoform X4

    See identical proteins and their annotated locations for XP_009442265.1

    UniProtKB/TrEMBL
    A0A2I3SAR9, A0A2I3T6Z1, A0A2J8N557, A0A2J8N562, A0A6D2VYS4, A0A6D2X698
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  8. XM_063791553.1 → XP_063647623.1  caspase-8 isoform X12

  9. XM_063791536.1 → XP_063647606.1  caspase-8 isoform X4

    UniProtKB/TrEMBL
    A0A2I3T6Z1, A0A2J8N557, A0A6D2VYS4

  10. XM_063791538.1 → XP_063647608.1  caspase-8 isoform X4

    UniProtKB/TrEMBL
    A0A2I3T6Z1, A0A2J8N557, A0A6D2VYS4

  11. XM_063791543.1 → XP_063647613.1  caspase-8 isoform X5

    UniProtKB/TrEMBL
    A0A2I3RN77, A0A2J8N566, A0A6D2WZ76

  12. XM_063791551.1 → XP_063647621.1  caspase-8 isoform X12

  13. XM_001172193.5 → XP_001172193.1  caspase-8 isoform X9

    See identical proteins and their annotated locations for XP_001172193.1

    UniProtKB/TrEMBL
    A0A2I3SAR9, A0A2J8N548, A0A2J8N562, A0A6D2WT42, A0A6D2X698, H2QJ86
    Related
    ENSPTRP00000021879.5
    Conserved Domains (3) summary
    cd00032
    Location:284 → 536
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:62 → 143
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:157 → 239
    DD; Death Domain Superfamily of protein-protein interaction domains

  14. XM_063791546.1 → XP_063647616.1  caspase-8 isoform X7

  15. XM_009443984.5 → XP_009442259.1  caspase-8 isoform X1

    UniProtKB/TrEMBL
    A0A2I3SAR9, A0A2J8N562, A0A6D2X698
    Conserved Domains (3) summary
    cd00032
    Location:269 → 521
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:62 → 143
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:157 → 239
    DD; Death Domain Superfamily of protein-protein interaction domains

  16. XM_063791554.1 → XP_063647624.1  caspase-8 isoform X12

  17. XM_016950288.4 → XP_016805777.1  caspase-8 isoform X6

    Related
    ENSPTRP00000091394.1

  18. XM_009443994.4 → XP_009442269.1  caspase-8 isoform X4

    See identical proteins and their annotated locations for XP_009442269.1

    UniProtKB/TrEMBL
    A0A2I3SAR9, A0A2I3T6Z1, A0A2J8N557, A0A2J8N562, A0A6D2VYS4, A0A6D2X698
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  19. XM_063791544.1 → XP_063647614.1  caspase-8 isoform X5

    UniProtKB/TrEMBL
    A0A2I3RN77, A0A2J8N566, A0A6D2WZ76

  20. XM_063791557.1 → XP_063647627.1  caspase-8 isoform X12

  21. XM_009443986.4 → XP_009442261.1  caspase-8 isoform X4

    See identical proteins and their annotated locations for XP_009442261.1

    UniProtKB/TrEMBL
    A0A2I3SAR9, A0A2I3T6Z1, A0A2J8N557, A0A2J8N562, A0A6D2VYS4, A0A6D2X698
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  22. XM_063791542.1 → XP_063647612.1  caspase-8 isoform X5

    UniProtKB/TrEMBL
    A0A2I3RN77, A0A2J8N566, A0A6D2WZ76

  23. XM_063791555.1 → XP_063647625.1  caspase-8 isoform X12

  24. XM_063791550.1 → XP_063647620.1  caspase-8 isoform X10

    UniProtKB/TrEMBL
    A0A2I3TR27, A0A2J8N558, A0A6D2WG63

  25. XM_009443991.5 → XP_009442266.1  caspase-8 isoform X4

    See identical proteins and their annotated locations for XP_009442266.1

    UniProtKB/TrEMBL
    A0A2I3SAR9, A0A2I3T6Z1, A0A2J8N557, A0A2J8N562, A0A6D2VYS4, A0A6D2X698
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  26. XM_063791548.1 → XP_063647618.1  caspase-8 isoform X8

  27. XM_016950287.4 → XP_016805776.1  caspase-8 isoform X2

    UniProtKB/TrEMBL
    A0A2I3SAR9, A0A2J8N562, A0A6D2X698

  28. XM_009443985.5 → XP_009442260.1  caspase-8 isoform X3

    UniProtKB/TrEMBL
    A0A2I3SAR9, A0A2J8N562, A0A6D2X698
    Conserved Domains (3) summary
    cd00032
    Location:284 → 495
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:62 → 143
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:157 → 239
    DD; Death Domain Superfamily of protein-protein interaction domains

  29. XM_054679220.2 → XP_054535195.1  caspase-8 isoform X5

    UniProtKB/TrEMBL
    A0A2I3RN77, A0A2J8N566, A0A6D2WZ76

  30. XM_063791540.1 → XP_063647610.1  caspase-8 isoform X5

    UniProtKB/TrEMBL
    A0A2I3RN77, A0A2J8N566, A0A6D2WZ76

  31. XM_063791547.1 → XP_063647617.1  caspase-8 isoform X8

  32. XM_009443987.5 → XP_009442262.1  caspase-8 isoform X4

    See identical proteins and their annotated locations for XP_009442262.1

    UniProtKB/TrEMBL
    A0A2I3SAR9, A0A2I3T6Z1, A0A2J8N557, A0A2J8N562, A0A6D2VYS4, A0A6D2X698
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  33. XM_063791549.1 → XP_063647619.1  caspase-8 isoform X10

    UniProtKB/TrEMBL
    A0A2I3TR27, A0A2J8N558, A0A6D2WG63

  34. XM_009443995.5 → XP_009442270.1  caspase-8 isoform X4

    See identical proteins and their annotated locations for XP_009442270.1

    UniProtKB/TrEMBL
    A0A2I3SAR9, A0A2I3T6Z1, A0A2J8N557, A0A2J8N562, A0A6D2VYS4, A0A6D2X698
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  35. XM_063791556.1 → XP_063647626.1  caspase-8 isoform X12

  36. XM_054679221.2 → XP_054535196.1  caspase-8 isoform X11

RNA

  1. XR_010150198.1 RNA Sequence

  2. XR_010150200.1 RNA Sequence

  3. XR_010150205.1 RNA Sequence

  4. XR_010150201.1 RNA Sequence

  5. XR_010150196.1 RNA Sequence

  6. XR_010150202.1 RNA Sequence

  7. XR_010150204.1 RNA Sequence

  8. XR_010150197.1 RNA Sequence

  9. XR_010150199.1 RNA Sequence

  10. XR_010150206.1 RNA Sequence

  11. XR_010150203.1 RNA Sequence

Nucleotide Protein
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