HIF1A hypoxia inducible factor 1 subunit alpha [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: HIF1Aprovided by VGNC
Official Full Name: hypoxia inducible factor 1 subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:8202
Locus tag: CK820_G0002614
See related: Ensembl:ENSPTRG00000006419
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 14

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	15	NC_072413.2 (59686674..59743604)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	14	NC_072412.1 (52955432..53008337)

Chromosome 15 - NC_072413.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

STS-U44754 (e-PCR)
- UniSTS:281

HIF1A (e-PCR)
- UniSTS:511803

D14S87E (e-PCR)
- UniSTS:147519

RH70592 (e-PCR)
- UniSTS:32832

MARC_6691-6694:992007331:1 (e-PCR)
- UniSTS:231249

MARC_6693-6692:992007336:1 (e-PCR)
- UniSTS:231250

G35879 (e-PCR)
- UniSTS:25950

RH93275 (e-PCR)
- UniSTS:85088

GDB:198173 (e-PCR)
- UniSTS:156026

GDB:198178 (e-PCR)
- UniSTS:156030

D14S1334 (e-PCR)
- UniSTS:77695

PMC212228P1 (e-PCR)
- UniSTS:272018

PMC212228P2 (e-PCR)
- UniSTS:272019

PMC212228P3 (e-PCR)
- UniSTS:272020

SGC35483 (e-PCR)
- UniSTS:72875

MARC_11585-11586:1002657151:1 (e-PCR)
- UniSTS:267233

MARC_11585-11586:1007154223:1 (e-PCR)
- UniSTS:267233

D14S87E (e-PCR)
- UniSTS:147452

HIF1A (e-PCR)
- UniSTS:278524

SHGC-83122 (e-PCR)
- UniSTS:101119

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: hypoxia-inducible factor 1-alpha

Names: hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); small nuclear RNA activating complex, polypeptide 1, 43kDa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072413.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

59686674..59743604

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009427907.4 → XP_009426182.1 hypoxia-inducible factor 1-alpha isoform X2

See identical proteins and their annotated locations for XP_009426182.1

UniProtKB/TrEMBL

A0A2I3RKE9, A0A2J8PI78, A0A6D2VTV6, K7D4V4

Related

ENSPTRP00000078653.1

Conserved Domains (5) summary

smart00091
Location:93 → 148

PAS; PAS domain

cd00083
Location:15 → 68

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam08778
Location:789 → 825

HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain

pfam08447
Location:254 → 339

PAS_3; PAS fold

pfam11413
Location:552 → 581

HIF-1; Hypoxia-inducible factor-1
XM_001168948.6 → XP_001168948.1 hypoxia-inducible factor 1-alpha isoform X6

See identical proteins and their annotated locations for XP_001168948.1

UniProtKB/TrEMBL

A0A2I3RKE9, A0A2J8PI97, A0A6D2W463, K7DRZ3

Related

ENSPTRP00000071638.1

Conserved Domains (4) summary

smart00091
Location:93 → 148

PAS; PAS domain

cd00083
Location:15 → 68

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam08447
Location:254 → 339

PAS_3; PAS fold

pfam11413
Location:552 → 581

HIF-1; Hypoxia-inducible factor-1
XM_024348744.3 → XP_024204512.1 hypoxia-inducible factor 1-alpha isoform X4

UniProtKB/TrEMBL

A0A2I3SVP9

Conserved Domains (5) summary

smart00091
Location:93 → 148

PAS; PAS domain

cd00083
Location:15 → 68

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam08778
Location:748 → 784

HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain

pfam08447
Location:254 → 339

PAS_3; PAS fold

pfam11413
Location:515 → 540

HIF-1; Hypoxia-inducible factor-1
XM_063792944.1 → XP_063649014.1 hypoxia-inducible factor 1-alpha isoform X8
XM_009427905.4 → XP_009426180.1 hypoxia-inducible factor 1-alpha isoform X1

See identical proteins and their annotated locations for XP_009426180.1

UniProtKB/TrEMBL

A0A2I3RKE9, A0A2J8PI90

Conserved Domains (5) summary

smart00091
Location:94 → 149

PAS; PAS domain

cd00083
Location:16 → 69

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam08778
Location:790 → 826

HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain

pfam08447
Location:255 → 340

PAS_3; PAS fold

pfam11413
Location:553 → 582

HIF-1; Hypoxia-inducible factor-1
XM_016926181.3 → XP_016781670.1 hypoxia-inducible factor 1-alpha isoform X3

UniProtKB/TrEMBL

A0A2I3SVP9

Related

ENSPTRP00000081091.1
XM_009427909.5 → XP_009426184.1 hypoxia-inducible factor 1-alpha isoform X5

UniProtKB/TrEMBL

A0A2I3RKE9

Conserved Domains (5) summary

smart00091
Location:94 → 149

PAS; PAS domain

cd00083
Location:16 → 69

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:240 → 339

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:255 → 340

PAS_3; PAS fold

pfam11413
Location:552 → 582

HIF-1; Hypoxia-inducible factor-1
XM_063792943.1 → XP_063649013.1 hypoxia-inducible factor 1-alpha isoform X7