MAPKAPK2 MAPK activated protein kinase 2 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: MAPKAPK2provided by VGNC
Official Full Name: MAPK activated protein kinase 2provided by VGNC
Primary source: VGNC:VGNC:8074
Locus tag: CK820_G0012803
See related: Ensembl:ENSPTRG00000001915
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	1	NC_072398.2 (42352891..42402386, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	1	NC_072398.1 (188920963..188970459)

Chromosome 1 - NC_072398.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

SHGC-76226 (e-PCR)
- UniSTS:67385

D1S3257 (e-PCR)
- UniSTS:9025

SHGC-34637 (e-PCR)
- UniSTS:59742

RH70252 (e-PCR)
- UniSTS:34662

SHGC-145653 (e-PCR)
- UniSTS:174709

RH70191 (e-PCR)
- UniSTS:56733

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calmodulin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables mitogen-activated protein kinase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to vascular endothelial growth factor stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: MAP kinase-activated protein kinase 2

Names: mitogen-activated protein kinase-activated protein kinase 2

XP_001164988.1

EC 2.7.11.1

XP_016792982.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072398.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

42352891..42402386 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001164988.8 → XP_001164988.1 MAP kinase-activated protein kinase 2 isoform X1

See identical proteins and their annotated locations for XP_001164988.1

UniProtKB/TrEMBL

A0A2J8QVV3, A0A6D2VWZ4, H2Q104, K7D549

Related

ENSPTRP00000003207.2

Conserved Domains (1) summary

cd14170
Location:61 → 363

STKc_MAPKAPK2; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2
XM_016937493.4 → XP_016792982.1 MAP kinase-activated protein kinase 2 isoform X2

UniProtKB/TrEMBL

K7D549