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VIPR2 vasoactive intestinal peptide receptor 2 [ Homo sapiens (human) ]

Gene ID: 7434, updated on 5-Mar-2024

Summary

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Official Symbol
VIPR2provided by HGNC
Official Full Name
vasoactive intestinal peptide receptor 2provided by HGNC
Primary source
HGNC:HGNC:12695
See related
Ensembl:ENSG00000106018 MIM:601970; AllianceGenome:HGNC:12695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VPAC2; VPAC2R; VIP-R-2; VPCAP2R; PACAP-R3; DUP7q36.3; PACAP-R-3; C16DUPq36.3
Summary
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
Expression
Broad expression in ovary (RPKM 1.9), brain (RPKM 1.9) and 20 other tissues See more
Orthologs
mouse all
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Genomic context

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See VIPR2 in Genome Data Viewer
Location:
7q36.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (159028175..159144867, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (160254532..160371379, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (158820866..158937559, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158768653-158769393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158806403-158807032 Neighboring gene LINC00689 intron CAGE-defined high expression enhancer Neighboring gene long intergenic non-protein coding RNA 689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158820859-158821787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158823906-158824558 Neighboring gene Sharpr-MPRA regulatory region 8832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158832214-158832714 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:158850668-158851867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158876624-158877154 Neighboring gene VISTA enhancer hs1753 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158905439-158906114 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:158939357-158940556 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:158961997-158963196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158984505-158985004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18875 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:159035435-159035650 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 2850

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway. Asano S, et al. Peptides, 2023 Mar. PMID 36603770
  2. AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys(25)-Cys(192)) formation of functional significance for VIPR2. Sakamoto K, et al. Biochem Biophys Res Commun, 2022 Dec 25. PMID 36332470
  3. Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia. Chen CH, et al. Psychiatr Genet, 2022 Jun 1. PMID 35353798
  4. The myopia susceptibility locus vasoactive intestinal peptide receptor 2 (VIPR2) contains variants with opposite effects. Leung KH, et al. Sci Rep, 2019 Dec 3. PMID 31796800, Free PMC Article
  5. Integrated genome analysis of uterine leiomyosarcoma to identify novel driver genes and targetable pathways. Cuppens T, et al. Int J Cancer, 2018 Mar 15. PMID 29063609

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Outdoor time influences VIPR2 polymorphism rs2071623 to regulate axial length in Han Chinese children.
    Title: Outdoor time influences VIPR2 polymorphism rs2071623 to regulate axial length in Han Chinese children.
  2. Seaweed intake modulates the association between VIPR2 variants and the incidence of metabolic syndrome in middle-aged Koreans.
    Title: Seaweed intake modulates the association between VIPR2 variants and the incidence of metabolic syndrome in middle-aged Koreans.
  3. TMEM132D and VIPR2 Polymorphisms as Genetic Risk Loci for Retinal Detachment: A Genome-Wide Association Study and Polygenic Risk Score Analysis.
    Title: TMEM132D and VIPR2 Polymorphisms as Genetic Risk Loci for Retinal Detachment: A Genome-Wide Association Study and Polygenic Risk Score Analysis.
  4. Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway.
    Title: Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway.
  5. PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
    Title: PAC(1), VPAC(1), and VPAC(2) Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
  6. AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys(25)-Cys(192)) formation of functional significance for VIPR2.
    Title: AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys(25)-Cys(192)) formation of functional significance for VIPR2.
  7. Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia.
    Title: Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia.
  8. Dysfunction of VIPR2 leads to myopia in humans and mice.
    Title: Dysfunction of VIPR2 leads to myopia in humans and mice.
  9. Association of VIPR2 and ZMAT4 with high myopia.
    Title: Association of VIPR2 and ZMAT4 with high myopia.
  10. The myopia susceptibility locus vasoactive intestinal peptide receptor 2 (VIPR2) contains variants with opposite effects.
    Title: The myopia susceptibility locus vasoactive intestinal peptide receptor 2 (VIPR2) contains variants with opposite effects.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16511

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables vasoactive intestinal polypeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
vasoactive intestinal polypeptide receptor 2
Names
PACAP type III receptor
VIP and PACAP receptor 2
helodermin-preferring VIP receptor
pituitary adenylate cyclase-activating polypeptide type III receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304522.2 → NP_001291451.1  vasoactive intestinal polypeptide receptor 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001291451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC004863, AK131406, AK308955, KJ534961
    UniProtKB/TrEMBL
    X5DP12
    Conserved Domains (2) summary
    smart00008
    Location:52 → 118
    HormR; Domain present in hormone receptors
    cl21561
    Location:120 → 291
    7tm_4; Olfactory receptor

  2. NM_001308259.1 → NP_001295188.1  vasoactive intestinal polypeptide receptor 2 isoform 3

    See identical proteins and their annotated locations for NP_001295188.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC004863, AK131406, CA449700
    Consensus CDS
    CCDS78295.1
    UniProtKB/Swiss-Prot
    P41587
    Related
    ENSP00000366860.3, ENST00000377633.7
    Conserved Domains (1) summary
    pfam00002
    Location:107 → 355
    7tm_2; 7 transmembrane receptor (Secretin family)

  3. NM_003382.5 → NP_003373.2  vasoactive intestinal polypeptide receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003373.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC004863, AC007269, AF027390, KC877184
    Consensus CDS
    CCDS5950.1
    UniProtKB/Swiss-Prot
    P41587, Q13053, Q15870, Q53Y09, Q6ZN22, Q9UCW0
    UniProtKB/TrEMBL
    X5D7Q6
    Related
    ENSP00000262178.2, ENST00000262178.7
    Conserved Domains (2) summary
    smart00008
    Location:52 → 118
    HormR; Domain present in hormone receptors
    cd15986
    Location:123 → 392
    7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_130758.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC004863, AC007269, AF027390, KC877184

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    159028175..159144867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    160254532..160371379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41587.2 GenPept UniProtKB/Swiss-Prot:P41587

Gene LinkOut

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