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JAK1 Janus kinase 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 743373, updated on 11-Apr-2024

Summary

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Official Symbol
JAK1provided by VGNC
Official Full Name
Janus kinase 1provided by VGNC
Primary source
VGNC:VGNC:1281
Locus tag
CK820_G0010395
See related
Ensembl:ENSPTRG00000000825
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 1 NC_072398.2 (165928185..166160628)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 1 NC_072398.1 (65138665..65271784, complement)

Chromosome 1 - NC_072398.2Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein uS14-like Neighboring gene adenylate kinase 4 Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene U6 spliceosomal RNA Neighboring gene microRNA mir-101-1 Neighboring gene solute carrier family 2, facilitated glucose transporter member 3-like Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene ribonucleoprotein, PTB binding 2 Neighboring gene cache domain containing 1 Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase JAK1
Names
Janus kinase 1 (a protein tyrosine kinase)
XP_016775408.1
XP_016775411.1
XP_016775413.1
XP_024202106.1
XP_054539915.1
XP_063657126.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072398.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    165928185..166160628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063801056.1 → XP_063657126.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    A0A2J8NHI2, A0A6D2WA31, H2PZ66

  2. XM_054683940.1 → XP_054539915.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    A0A2J8NHI2, A0A6D2WA31, H2PZ66

  3. XM_016919919.3 → XP_016775408.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    A0A2I3RU79, A0A2J8NHI2, A0A6D2WA31, H2PZ66
    Conserved Domains (5) summary
    cd05079
    Location:870 → 1153
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    smart00295
    Location:37 → 286
    B41; Band 4.1 homologues
    cd05077
    Location:583 → 846
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    cl15255
    Location:426 → 527
    SH2; Src homology 2 (SH2) domain

  4. XM_024346338.3 → XP_024202106.1  tyrosine-protein kinase JAK1 isoform X2

    UniProtKB/TrEMBL
    A0A2I3RU79
    Conserved Domains (5) summary
    cd05079
    Location:869 → 1152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    smart00295
    Location:37 → 286
    B41; Band 4.1 homologues
    cd05077
    Location:582 → 845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    cl15255
    Location:426 → 526
    SH2; Src homology 2 (SH2) domain

  5. XM_016919922.3 → XP_016775411.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    A0A2I3RU79, A0A2J8NHI2, A0A6D2WA31, H2PZ66
    Conserved Domains (5) summary
    cd05079
    Location:870 → 1153
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    smart00295
    Location:37 → 286
    B41; Band 4.1 homologues
    cd05077
    Location:583 → 846
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    cl15255
    Location:426 → 527
    SH2; Src homology 2 (SH2) domain

  6. XM_016919924.4 → XP_016775413.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    A0A2I3RU79, A0A2J8NHI2, A0A6D2WA31, H2PZ66
    Related
    ENSPTRP00000001425.4
    Conserved Domains (5) summary
    cd05079
    Location:870 → 1153
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    smart00295
    Location:37 → 286
    B41; Band 4.1 homologues
    cd05077
    Location:583 → 846
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282 → 426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    cl15255
    Location:426 → 527
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein
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