MDM2 MDM2 proto-oncogene [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: MDM2provided by VGNC
Official Full Name: MDM2 proto-oncogeneprovided by VGNC
Primary source: VGNC:VGNC:8605
Locus tag: CK820_G0041484
See related: Ensembl:ENSPTRG00000005203
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	10	NC_072408.2 (75547005..75582187)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	12	NC_072410.1 (74160029..74200079)

Chromosome 10 - NC_072408.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

RH93271 (e-PCR)
- UniSTS:91925

D10S275 (e-PCR)
- UniSTS:147992

G66928 (e-PCR)
- UniSTS:166955

G66929 (e-PCR)
- UniSTS:166956

RH45825 (e-PCR)
- UniSTS:69681

D8S2278 (e-PCR)
- UniSTS:473906

NoName (e-PCR)
- UniSTS:484679

SGC38056 (e-PCR)
- UniSTS:50520

GDB:451622 (e-PCR)
- UniSTS:157329

RH45597 (e-PCR)
- UniSTS:9389

L18441 (e-PCR)
- UniSTS:71348

RH65828 (e-PCR)
- UniSTS:187

STS-H58373 (e-PCR)
- UniSTS:71615

GDB:371587 (e-PCR)
- UniSTS:156866

RH80031 (e-PCR)
- UniSTS:91103

RH11003 (e-PCR)
- UniSTS:87522

PMC100259P1 (e-PCR)
- UniSTS:270055

MDM2_1161 (e-PCR)
- UniSTS:277486

L17791 (e-PCR)
- UniSTS:42740

PMC129072P1 (e-PCR)
- UniSTS:270587

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables p53 binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase Mdm2

Names: MDM2 proto-oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein

XP_001155208.1

EC 2.3.2.27

XP_016779327.1

EC 2.3.2.27

XP_063642970.1

EC 2.3.2.27

XP_063642971.1

EC 2.3.2.27

XP_063642973.1

EC 2.3.2.27

XP_063642974.1

EC 2.3.2.27

XP_063642975.1

EC 2.3.2.27

XP_063642976.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

75547005..75582187

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001155208.8 → XP_001155208.1 E3 ubiquitin-protein ligase Mdm2 isoform X1

See identical proteins and their annotated locations for XP_001155208.1

UniProtKB/TrEMBL

A0A2J8K4Q8, A0A6D2WGI6, H2R792, K7BM52

Related

ENSPTRP00000050081.2

Conserved Domains (3) summary

pfam00641
Location:305 → 334

zf-RanBP; Zn-finger in Ran binding protein and others

pfam02201
Location:51 → 102

SWIB; SWIB/MDM2 domain

cd16783
Location:441 → 497

mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
XM_063786901.1 → XP_063642971.1 E3 ubiquitin-protein ligase Mdm2 isoform X3
XM_016923838.4 → XP_016779327.1 E3 ubiquitin-protein ligase Mdm2 isoform X4

UniProtKB/TrEMBL

A0A2I3TD93, A0A2J8K4V5, A0A6D2VYZ1, K7BM52

Related

ENSPTRP00000087166.1

Conserved Domains (3) summary

pfam00641
Location:250 → 279

zf-RanBP; Zn-finger in Ran binding protein and others

pfam02201
Location:51 → 102

SWIB; SWIB/MDM2 domain

cd16783
Location:386 → 442

mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
XM_063786900.1 → XP_063642970.1 E3 ubiquitin-protein ligase Mdm2 isoform X2
XM_063786905.1 → XP_063642975.1 E3 ubiquitin-protein ligase Mdm2 isoform X6
XM_063786903.1 → XP_063642973.1 E3 ubiquitin-protein ligase Mdm2 isoform X5
XM_063786906.1 → XP_063642976.1 E3 ubiquitin-protein ligase Mdm2 isoform X7
XM_063786904.1 → XP_063642974.1 E3 ubiquitin-protein ligase Mdm2 isoform X6