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Gtf2e1 general transcription factor II E, polypeptide 1 (alpha subunit) [ Mus musculus (house mouse) ]

Gene ID: 74197, updated on 11-Apr-2024

Summary

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Official Symbol
Gtf2e1provided by MGI
Official Full Name
general transcription factor II E, polypeptide 1 (alpha subunit)provided by MGI
Primary source
MGI:MGI:1921447
See related
Ensembl:ENSMUSG00000022828 AllianceGenome:MGI:1921447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FE; 56kDa; TFIIE-A; 2610024P03Rik
Summary
Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in transcription open complex formation at RNA polymerase II promoter. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription factor TFIID complex; transcription factor TFIIE complex; and transcription preinitiation complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human GTF2E1 (general transcription factor IIE subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 12.8), CNS E14 (RPKM 8.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Gtf2e1 in Genome Data Viewer
Location:
16 B3; 16 26.38 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (37330158..37360151, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (37509796..37539789, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene syntaxin binding protein 5-like Neighboring gene LIM and senescent cell antigen like domains 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40782 Neighboring gene predicted gene, 57640 Neighboring gene STARR-seq mESC enhancer starr_40783 Neighboring gene STARR-positive B cell enhancer ABC_E2461 Neighboring gene RAB, member RAS oncogene family-like 3 Neighboring gene predicted gene, 46559 Neighboring gene homogentisate 1, 2-dioxygenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation. Alpern D, et al. Elife, 2014 Sep 10. PMID 25209997, Free PMC Article
  2. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595, Free PMC Article
  3. Oct4 links multiple epigenetic pathways to the pluripotency network. Ding J, et al. Cell Res, 2012 Jan. PMID 22083510, Free PMC Article
  4. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription open complex formation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIE complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
general transcription factor IIE subunit 1
Names
TFIIE-alpha
general transcription factor II E, polypeptide 1 (alpha subunit, 56kDa)
general transcription factor IIE 56 kDa subunit
general transcription factor IIE, polypeptide 1 (alpha subunit, 56kDa)
transcription initiation factor IIE subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355727.1 → NP_001342656.1  general transcription factor IIE subunit 1

    Status: VALIDATED

    Source sequence(s)
    AC154762
    Consensus CDS
    CCDS28160.1
    UniProtKB/Swiss-Prot
    Q544T0, Q9D0D5
    UniProtKB/TrEMBL
    Q8BV40
    Conserved Domains (2) summary
    smart00531
    Location:28 → 175
    TFIIE; Transcription initiation factor IIE
    pfam11521
    Location:395 → 440
    TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

  2. NM_028812.4 → NP_083088.1  general transcription factor IIE subunit 1

    See identical proteins and their annotated locations for NP_083088.1

    Status: VALIDATED

    Source sequence(s)
    AC154762
    Consensus CDS
    CCDS28160.1
    UniProtKB/Swiss-Prot
    Q544T0, Q9D0D5
    UniProtKB/TrEMBL
    Q8BV40
    Related
    ENSMUSP00000023525.9, ENSMUST00000023525.9
    Conserved Domains (2) summary
    smart00531
    Location:28 → 175
    TFIIE; Transcription initiation factor IIE
    pfam11521
    Location:395 → 440
    TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    37330158..37360151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0D5.1 GenPept UniProtKB/Swiss-Prot:Q9D0D5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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