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Stk40 serine/threonine kinase 40 [ Mus musculus (house mouse) ]

Gene ID: 74178, updated on 5-Mar-2024

Summary

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Official Symbol
Stk40provided by MGI
Official Full Name
serine/threonine kinase 40provided by MGI
Primary source
MGI:MGI:1921428
See related
Ensembl:ENSMUSG00000042608 AllianceGenome:MGI:1921428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310004N11Rik
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Acts upstream of or within several processes, including glycogen metabolic process; lung development; and respiratory system process. Predicted to be located in cytosol and nucleoplasm. Is expressed in alimentary system; central nervous system; pharyngo-tympanic tube; and skin. Orthologous to human STK40 (serine/threonine kinase 40). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 18.0), lung adult (RPKM 15.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stk40 in Genome Data Viewer
Location:
4 D2.2; 4 59.89 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125997738..126034822)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126103942..126141029)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene organic solute carrier partner 1 Neighboring gene ribosomal protein L28, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E2712 Neighboring gene STARR-positive B cell enhancer ABC_E2713 Neighboring gene U7 snRNP-specific Sm-like protein LSM10 Neighboring gene eva-1 homolog B Neighboring gene SH3 domain containing 21 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:125839584-125839767

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of transcription factor Stk40 expression and function during mouse pre-implantation embryonic development. Zhang J, et al. Mol Med Rep, 2014 Feb. PMID 24276375
  2. EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression. Cai B, et al. Aging (Albany NY), 2020 Jul 12. PMID 32657761, Free PMC Article
  3. Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteins. Yu H, et al. J Cell Sci, 2015 Aug 1. PMID 26065429
  4. Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway. Wacker BK, et al. J Neurochem, 2012 Dec. PMID 23043544, Free PMC Article
  5. Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation. Li L, et al. Proc Natl Acad Sci U S A, 2010 Jan 26. PMID 20080709, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression.
    Title: EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression.
  2. comparison of microarray data between wild type and Stk40(-/-) E14.5 fetal liver cells reveals a potential role of aberrantly activated TNF-alpha signaling in Stk40 depletion induced dyserythropoiesis with a concomitant increase in cleaved caspase-3 and decrease in Gata1 proteins.
    Title: Deletion of Stk40 impairs definitive erythropoiesis in the mouse fetal liver.
  3. Loss of Stk40 is associated with impaired fetal skeletal muscle formation.
    Title: Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation.
  4. CCAAT/enhancer-binding protein (C/EBP) beta and C/EBPdelta, two crucial pro-adipogenic transcription factors, are controlled at a translational level by serine/threonine kinase 40 (Stk40).
    Title: Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteins.
  5. the results suggested that Stk40 may be critical in the development of preimplantation embryos.
    Title: Analysis of transcription factor Stk40 expression and function during mouse pre-implantation embryonic development.
  6. Deletion of STK40 protein in mice causes respiratory failure and death at birth
    Title: Deletion of STK40 protein in mice causes respiratory failure and death at birth.
  7. report identification of a target gene of Oct4, serine/threonine kinase 40 (Stk40), which is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse embryonic stem cells.
    Title: Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within respiratory system process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 40
Names
ortholog of Ser/Thr-like protein kinase Lyk4
serine/threonine-protein kinase lyk4
NP_001139299.1
NP_083076.3
XP_006503504.1
XP_006503505.1
XP_017175903.1
XP_036020388.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145827.1 → NP_001139299.1  serine/threonine-protein kinase 40 isoform a

    See identical proteins and their annotated locations for NP_001139299.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL731780, AY336057, BQ030783, CJ170090, DV660319
    Consensus CDS
    CCDS51299.1
    UniProtKB/Swiss-Prot
    Q7TNL3
    Related
    ENSMUSP00000111990.3, ENSMUST00000116286.9
    Conserved Domains (1) summary
    cd13974
    Location:52 → 344
    STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

  2. NM_028800.3 → NP_083076.3  serine/threonine-protein kinase 40 isoform b

    See identical proteins and their annotated locations for NP_083076.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AY336057, BQ030783, CJ170090, DV660319
    Consensus CDS
    CCDS51300.1
    UniProtKB/Swiss-Prot
    B1AW01, Q3U3G3, Q7TNL3, Q811D6, Q8BKT1, Q9D7K3
    Related
    ENSMUSP00000092354.5, ENSMUST00000094761.11
    Conserved Domains (1) summary
    cd13974
    Location:38 → 330
    STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    125997738..126034822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320414.3 → XP_017175903.1  serine/threonine-protein kinase 40 isoform X2

    UniProtKB/Swiss-Prot
    B1AW01, Q3U3G3, Q7TNL3, Q811D6, Q8BKT1, Q9D7K3
    Conserved Domains (1) summary
    cd13974
    Location:38 → 330
    STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

  2. XM_006503442.3 → XP_006503505.1  serine/threonine-protein kinase 40 isoform X2

    See identical proteins and their annotated locations for XP_006503505.1

    UniProtKB/Swiss-Prot
    B1AW01, Q3U3G3, Q7TNL3, Q811D6, Q8BKT1, Q9D7K3
    Conserved Domains (1) summary
    cd13974
    Location:38 → 330
    STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

  3. XM_006503441.5 → XP_006503504.1  serine/threonine-protein kinase 40 isoform X1

    See identical proteins and their annotated locations for XP_006503504.1

    UniProtKB/Swiss-Prot
    Q7TNL3
    Conserved Domains (1) summary
    cd13974
    Location:52 → 344
    STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

  4. XM_036164495.1 → XP_036020388.1  serine/threonine-protein kinase 40 isoform X2

    UniProtKB/Swiss-Prot
    B1AW01, Q3U3G3, Q7TNL3, Q811D6, Q8BKT1, Q9D7K3
    Conserved Domains (1) summary
    cd13974
    Location:38 → 330
    STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNL3.1 GenPept UniProtKB/Swiss-Prot:Q7TNL3

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