Rbm19 RNA binding motif protein 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbm19provided by MGI
Official Full Name: RNA binding motif protein 19provided by MGI
Primary source: MGI:MGI:1921361
See related: Ensembl:ENSMUSG00000029594 AllianceGenome:MGI:1921361
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NPO; 1200009A02Rik
Summary: Predicted to enable RNA binding activity. Involved in positive regulation of embryonic development. Located in cytoplasm; nucleolus; and nucleoplasm. Is expressed in brain and gut. Orthologous to human RBM19 (RNA binding motif protein 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 4.9), ovary adult (RPKM 4.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 60.58 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (120254578..120337036)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (120116513..120198971)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RBM19 is essential for preimplantation development, highlighting the importance of de novo nucleologenesis during this critical developmental stage.
Title: RBM19 is essential for preimplantation development in the mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV302714 (e-PCR)
- UniSTS:164296

AW553963 (e-PCR)
- UniSTS:207863

Rbm19 (e-PCR), detects polymorphism
- UniSTS:479227

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable RNA-binding protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028762.1 → NP_083038.1 probable RNA-binding protein 19

See identical proteins and their annotated locations for NP_083038.1

Status: PROVISIONAL

Source sequence(s)

BC025619

Consensus CDS

CCDS19616.1

UniProtKB/Swiss-Prot

Q8BHR0, Q8R3C6, Q9CW63

UniProtKB/TrEMBL

A0A0J9YUT8

Related

ENSMUSP00000031590.9, ENSMUST00000031590.12

Conserved Domains (8) summary

COG0724
Location:2 → 183

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12318
Location:722 → 801

RRM5_RBM19_like; RNA recognition motif 5 in RNA-binding protein 19 (RBM19 or RBD-1) and similar proteins

cd12502
Location:293 → 364

RRM2_RMB19; RNA recognition motif 2 in RNA-binding protein 19 (RBM19) and similar proteins

cd12564
Location:2 → 77

RRM1_RBM19; RNA recognition motif 1 in RNA-binding protein 19 (RBM19) and similar proteins

cd12567
Location:398 → 476

RRM3_RBM19; RNA recognition motif 3 in RNA-binding protein 19 (RBM19) and similar proteins

cd12569
Location:584 → 655

RRM4_RBM19; RNA recognition motif 4 in RNA-binding protein 19 (RBM19) and similar proteins

cd12571
Location:824 → 902

RRM6_RBM19; RNA recognition motif 6 in RNA-binding protein 19 (RBM19) and similar proteins

TIGR01661
Location:402 → 798

ELAV_HUD_SF; ELAV/HuD family splicing factor