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PSEN1 presenilin 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 739740, updated on 3-Apr-2024

Summary

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Official Symbol
PSEN1provided by VGNC
Official Full Name
presenilin 1provided by VGNC
Primary source
VGNC:VGNC:3326
Locus tag
CK820_G0002833
See related
Ensembl:ENSPTRG00000006510
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 15 NC_072413.2 (71113122..71194274)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 14 NC_072412.1 (64408611..64489756)

Chromosome 15 - NC_072413.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104002098 Neighboring gene required for meiotic nuclear division protein 1 homolog Neighboring gene RNA binding motif protein 25 Neighboring gene uncharacterized LOC134808373 Neighboring gene U6 spliceosomal RNA Neighboring gene papilin, proteoglycan like sulfated glycoprotein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smooth endoplasmic reticulum calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
Presenilin-1; presenilin-1
Names
presenilin 1 (Alzheimer disease 3)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072413.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    71113122..71194274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016926347.4 → XP_016781836.1  presenilin-1 isoform X3

    UniProtKB/TrEMBL
    A0A2I3RBB3, A0A2J8PJA0, A0A2J8PJB9, A0A6D2XJV1, A0A803KLE9, K7CVQ1
    Conserved Domains (1) summary
    pfam01080
    Location:72 → 453
    Presenilin

  2. XM_016926341.4 → XP_016781830.1  presenilin-1 isoform X2

    UniProtKB/TrEMBL
    A0A2I3RBB3, A0A2J8PJB3, A0A2J8PJB9, A0A6D2X6D4, A0A6D2XJV1, H2Q8K1
    Related
    ENSPTRP00000061908.1
    Conserved Domains (1) summary
    pfam01080
    Location:76 → 457
    Presenilin

  3. XM_016926336.3 → XP_016781825.1  presenilin-1 isoform X1

  4. XM_063793652.1 → XP_063649722.1  presenilin-1 isoform X2

    UniProtKB/TrEMBL
    A0A2J8PJB3, A0A6D2X6D4, H2Q8K1

  5. XM_063793653.1 → XP_063649723.1  presenilin-1 isoform X3

    UniProtKB/TrEMBL
    A0A2J8PJA0, A0A803KLE9, K7CVQ1

  6. XM_016926343.4 → XP_016781832.1  presenilin-1 isoform X3

    UniProtKB/TrEMBL
    A0A2I3RBB3, A0A2J8PJA0, A0A2J8PJB9, A0A6D2XJV1, A0A803KLE9, K7CVQ1
    Conserved Domains (1) summary
    pfam01080
    Location:72 → 453
    Presenilin

  7. XM_016926338.3 → XP_016781827.1  presenilin-1 isoform X2

    UniProtKB/TrEMBL
    A0A2I3RBB3, A0A2J8PJB3, A0A2J8PJB9, A0A6D2X6D4, A0A6D2XJV1, H2Q8K1
    Conserved Domains (1) summary
    pfam01080
    Location:76 → 457
    Presenilin

  8. XM_016926344.4 → XP_016781833.1  presenilin-1 isoform X3

    UniProtKB/TrEMBL
    A0A2I3RBB3, A0A2J8PJA0, A0A2J8PJB9, A0A6D2XJV1, A0A803KLE9, K7CVQ1
    Conserved Domains (1) summary
    pfam01080
    Location:72 → 453
    Presenilin

  9. XM_016926340.4 → XP_016781829.1  presenilin-1 isoform X2

    UniProtKB/TrEMBL
    A0A2I3RBB3, A0A2J8PJB3, A0A2J8PJB9, A0A6D2X6D4, A0A6D2XJV1, H2Q8K1
    Related
    ENSPTRP00000011045.4
    Conserved Domains (1) summary
    pfam01080
    Location:76 → 457
    Presenilin

  10. XM_016926339.4 → XP_016781828.1  presenilin-1 isoform X2

    UniProtKB/TrEMBL
    A0A2I3RBB3, A0A2J8PJB3, A0A2J8PJB9, A0A6D2X6D4, A0A6D2XJV1, H2Q8K1
    Conserved Domains (1) summary
    pfam01080
    Location:76 → 457
    Presenilin

  11. XM_016926346.4 → XP_016781835.1  presenilin-1 isoform X3

    UniProtKB/TrEMBL
    A0A2I3RBB3, A0A2J8PJA0, A0A2J8PJB9, A0A6D2XJV1, A0A803KLE9, K7CVQ1
    Conserved Domains (1) summary
    pfam01080
    Location:72 → 453
    Presenilin

  12. XM_063793655.1 → XP_063649725.1  presenilin-1 isoform X4

  13. XM_016926348.4 → XP_016781837.1  presenilin-1 isoform X4

    UniProtKB/TrEMBL
    A0A2I3TCR8, A0A2J8PJA6, A0A6D2XVI8
    Related
    ENSPTRP00000087035.1
    Conserved Domains (1) summary
    pfam01080
    Location:1 → 374
    Presenilin
Nucleotide Protein
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