PLAU plasminogen activator, urokinase [Pan troglodytes (chimpanzee)] - Gene

Summary

Gene symbol: PLAU
Gene description: plasminogen activator, urokinase
Locus tag: CK820_G0007835
See related: Ensembl:ENSPTRG00000002646
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	8	NC_072406.2 (86133212..86141609)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	10	NC_072408.1 (76753375..76761597)

Chromosome 8 - NC_072406.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

PMC229370P1 (e-PCR)
- UniSTS:272175

PLAU (e-PCR), detects polymorphism
- UniSTS:266574

RH92165 (e-PCR)
- UniSTS:85102

GDB:181547 (e-PCR)
- UniSTS:155273

PLAU_226 (e-PCR)
- UniSTS:468108

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in fibrinolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in plasminogen activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: urokinase-type plasminogen activator

Names: urokinase plasminogen activator

XP_009457026.2

EC 3.4.21.73

XP_063637970.1

EC 3.4.21.73

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072406.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

86133212..86141609

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009458751.4 → XP_009457026.2 urokinase-type plasminogen activator

UniProtKB/TrEMBL

A0A2J8NUA3, A0A6D2XWS2, H2Q245, K7AVB0, K7CJD2

Related

ENSPTRP00000073321.1

Conserved Domains (2) summary

cd00108
Location:67 → 152

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00190
Location:179 → 422

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_063781900.1 → XP_063637970.1 urokinase-type plasminogen activator

UniProtKB/TrEMBL

A0A2J8NUA3, A0A6D2XWS2, H2Q245, K7CJD2