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Dppa4 developmental pluripotency associated 4 [ Mus musculus (house mouse) ]

Gene ID: 73693, updated on 21-Apr-2024

Summary

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Official Symbol
Dppa4provided by MGI
Official Full Name
developmental pluripotency associated 4provided by MGI
Primary source
MGI:MGI:2157525
See related
Ensembl:ENSMUSG00000058550 AllianceGenome:MGI:2157525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ECAT15-1; 2410091M23Rik
Summary
Predicted to enable chromatin binding activity. Acts upstream of or within lung-associated mesenchyme development. Located in nucleus. Is expressed in several structures, including alimentary system; diencephalon lateral wall ventricular layer; early embryo; gonad; and nose. Orthologous to human DPPA4 (developmental pluripotency associated 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
16 B5; 16 30.75 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (48104098..48114655)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (48283735..48294292)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6430553K19 gene Neighboring gene STARR-seq mESC enhancer starr_40937 Neighboring gene peroxiredoxin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40940 Neighboring gene STARR-seq mESC enhancer starr_40944 Neighboring gene developmental pluripotency associated 2 Neighboring gene predicted gene 5485

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DPPA4 modulates chromatin structure via association with DNA and core histone H3 in mouse embryonic stem cells. Masaki H, et al. Genes Cells, 2010 Apr 1. PMID 20298437
  2. The pluripotency-associated gene Dppa4 is dispensable for embryonic stem cell identity and germ cell development but essential for embryogenesis. Madan B, et al. Mol Cell Biol, 2009 Jun. PMID 19332562, Free PMC Article
  3. Developmental pluripotency-associated 4 (DPPA4) localized in active chromatin inhibits mouse embryonic stem cell differentiation into a primitive ectoderm lineage. Masaki H, et al. J Biol Chem, 2007 Nov 9. PMID 17855347
  4. Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development. Gretarsson KH, et al. Nat Struct Mol Biol, 2020 Aug. PMID 32572256
  5. Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment. Eckersley-Maslin MA, et al. Nat Struct Mol Biol, 2020 Aug. PMID 32572255, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival.
    Title: Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival.
  2. DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development.
    Title: DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development.
  3. Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region.
    Title: Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region.
  4. Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development.
    Title: Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development.
  5. Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment.
    Title: Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment.
  6. Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome.
    Title: Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome.
  7. The paralog proteins DPPA2 and DPPA4 as necessary for the activation of Dux and LINE-1 expression in mESCs.
    Title: DPPA2 and DPPA4 are necessary to establish a 2C-like state in mouse embryonic stem cells.
  8. Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency
    Title: Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency.
  9. identifies EBP1 as a novel pluripotency cofactor and provides insight into potential mechanisms used by DPPA4 in regulating pluripotency through its association with EBP1
    Title: ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells.
  10. Dppa2 and Dppa4 directly regulate the 2C-like cell population and associated transcripts, including Dux and the Zscan4 cluster.
    Title: Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lung-associated mesenchyme development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lung-associated mesenchyme development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
developmental pluripotency-associated protein 4
Names
embryonic stem cell-associated transcript 15-1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018002.1 → NP_001018002.1  developmental pluripotency-associated protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, as compared to variant 1. The encoded isoform (2) thus lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AK033197, BY731814, CAAA01133063
    Consensus CDS
    CCDS28208.1
    UniProtKB/TrEMBL
    E9PUG8
    Related
    ENSMUSP00000093748.2, ENSMUST00000050705.4
    Conserved Domains (2) summary
    pfam14047
    Location:169 → 235
    DCR; Dppa2/4 conserved region
    pfam14049
    Location:73 → 157
    Dppa2_A; Dppa2/4 conserved region in higher vertebrates

  2. NM_028610.2 → NP_082886.2  developmental pluripotency-associated protein 4 isoform 1

    See identical proteins and their annotated locations for NP_082886.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK033197, BC064754, CAAA01133063
    Consensus CDS
    CCDS28209.1
    UniProtKB/Swiss-Prot
    Q6P228, Q810Y6, Q8CCG4
    Related
    ENSMUSP00000093749.2, ENSMUST00000096045.9
    Conserved Domains (2) summary
    pfam14047
    Location:221 → 287
    DCR; Dppa2/4 conserved region
    pfam14049
    Location:125 → 209
    Dppa2_A; Dppa2/4 conserved region in higher vertebrates

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    48104098..48114655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CCG4.2 GenPept UniProtKB/Swiss-Prot:Q8CCG4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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