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hrh1 histamine receptor H1 [ Danio rerio (zebrafish) ]

Gene ID: 735302, updated on 27-Mar-2024

Summary

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Official Symbol
hrh1provided by ZNC
Official Full Name
histamine receptor H1provided by ZNC
Primary source
ZFIN:ZDB-GENE-070531-3
See related
AllianceGenome:ZFIN:ZDB-GENE-070531-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables histamine receptor activity. Predicted to act upstream of or within several processes, including eosinophil chemotaxis; positive regulation of vasoconstriction; and regulation of vascular permeability. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in brain; gill; liver; and pleuroperitoneal region. Orthologous to human HRH1 (histamine receptor H1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (900514..906768, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (874025..880166, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene vestigial-like family member 4b Neighboring gene ATG7 autophagy related 7 homolog (S. cerevisiae) Neighboring gene solute carrier family 6 member 1b Neighboring gene uncharacterized LOC100003140

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genomic and functional conservation of sedative-hypnotic targets in the zebrafish. Renier C, et al. Pharmacogenet Genomics, 2007 Apr. PMID 17496723
  2. Identification of zebrafish histamine H1, H2 and H3 receptors and effects of histaminergic ligands on behavior. Peitsaro N, et al. Biochem Pharmacol, 2007 Apr 15. PMID 17266939
  3. Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep. Chen A, et al. eNeuro, 2017 Jan-Feb. PMID 28275716, Free PMC Article
  4. The bullies are the leaders of the next generation: Inherited aminergic neurotransmitter system changes in socially dominant zebrafish, Danio rerio. Sundvik M, et al. Behav Brain Res, 2021 Jul 9. PMID 33878430
  5. The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish. Sundvik M, et al. FASEB J, 2011 Dec. PMID 21885652

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Roles of Histamine Receptor 1 (hrh1) in Neurotransmitter System Regulation, Behavior, and Neurogenesis in Zebrafish.
    Title: The Roles of Histamine Receptor 1 (hrh1) in Neurotransmitter System Regulation, Behavior, and Neurogenesis in Zebrafish.
  2. The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1.
    Title: The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables histamine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histamine receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histamine H1 receptor
Names
7 transmembrane receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042731.1 → NP_001036196.1  histamine H1 receptor

    See identical proteins and their annotated locations for NP_001036196.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ647806
    UniProtKB/TrEMBL
    Q195J2
    Conserved Domains (2) summary
    pfam00001
    Location:69 → 249
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:63 → 242
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    900514..906768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009305727.3 → XP_009304002.1  histamine H1 receptor isoform X1

    See identical proteins and their annotated locations for XP_009304002.1

    UniProtKB/TrEMBL
    A0A8M3B6M8
    Conserved Domains (2) summary
    pfam00001
    Location:69 → 249
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:63 → 242
    7tm_4; Olfactory receptor
Nucleotide Protein
Heading Accession and Version

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