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limk1a LIM domain kinase 1a [ Danio rerio (zebrafish) ]

Gene ID: 735292, updated on 11-Apr-2024

Summary

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Official Symbol
limk1aprovided by ZNC
Official Full Name
LIM domain kinase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061212-3
See related
Ensembl:ENSDARG00000103467 AllianceGenome:ZFIN:ZDB-GENE-061212-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
limk1
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within response to yeast. Predicted to be active in cytoplasm; neuron projection; and nucleus. Is expressed in several structures, including blood vessel; digestive system; fin; nervous system; and pronephric duct. Orthologous to human LIMK1 (LIM domain kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See limk1a in Genome Data Viewer
Location:
chromosome: 15
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (166139..252813, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (256700..343372, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein A-Ib Neighboring gene septin 4b Neighboring gene elastin a Neighboring gene uncharacterized LOC103908786

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative analysis of splice form-specific expression of LIM Kinases during zebrafish development. Ott EB, et al. Gene Expr Patterns, 2007 Apr. PMID 17300993
  2. RNA structure replaces the need for U2AF2 in splicing. Lin CL, et al. Genome Res, 2016 Jan. PMID 26566657, Free PMC Article
  3. Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. Wang YC, et al. BMC Syst Biol, 2013 Aug 16. PMID 23947337, Free PMC Article
  4. Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). Messina A, et al. Eur J Neurosci, 2021 Jan. PMID 32692463
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to yeast IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LIM domain kinase 1; LIM domain kinase 1a
NP_001036156.1
XP_005169702.1
XP_005169703.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042691.2 → NP_001036156.1  LIM domain kinase 1a

    See identical proteins and their annotated locations for NP_001036156.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ679229
    UniProtKB/TrEMBL
    Q0PWB7
    Related
    ENSDARP00000132730.1, ENSDART00000163441.2
    Conserved Domains (5) summary
    cd09462
    Location:5 → 79
    LIM1_LIMK1; The first LIM domain of LIMK1 (LIM domain Kinase 1)
    smart00219
    Location:346 → 603
    TyrKc; Tyrosine kinase, catalytic domain
    cd14221
    Location:349 → 610
    STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
    pfam00595
    Location:164 → 254
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:86 → 140
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    166139..252813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169646.4 → XP_005169703.1  LIM domain kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BHH8
    Conserved Domains (5) summary
    cd09464
    Location:66 → 120
    LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
    smart00219
    Location:326 → 583
    TyrKc; Tyrosine kinase, catalytic domain
    cd14221
    Location:329 → 590
    STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
    pfam00595
    Location:144 → 234
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:34 → 59
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_005169645.4 → XP_005169702.1  LIM domain kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BGY7
    Conserved Domains (4) summary
    smart00219
    Location:268 → 525
    TyrKc; Tyrosine kinase, catalytic domain
    cd14221
    Location:271 → 532
    STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
    pfam00595
    Location:86 → 176
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:22 → 62
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein
Heading Accession and Version

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